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Adenomatous Polyposis Coli

Known as: Colus, Polyposis, Adenomatous Polyposis Colus, Familial Polyposis Syndrome 
An autosomal dominant disorder, characterized by the presence of multiple adenomas in the colon and rectum. It is caused by a germline mutation in… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Several families have been reported with autosomal-dominant frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS… Expand
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Highly Cited
2008
Highly Cited
2008
Inactivation of the adenomatous polyposis coli (APC) gene is a major initiating event in colorectal tumorigenesis. Most of the… Expand
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Highly Cited
2003
Highly Cited
2003
Cell polarity is a fundamental property of all cells. In higher eukaryotes, the small GTPase Cdc42, acting through a Par6… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple… Expand
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Highly Cited
2000
Highly Cited
2000
Germ-line mutations in the tumor suppressor gene APC are associated with hereditary familial adenomatous polyposis (FAP), and… Expand
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Highly Cited
1999
Highly Cited
1999
Ectopic expression of certain Wnt genes in mouse mammary tissue is tumorigenic, and mutations that stabilize beta-catenin are… Expand
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Highly Cited
1996
Highly Cited
1996
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2… Expand
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Highly Cited
1995
Highly Cited
1995
The APC tumor-suppressor protein associates with beta-catenin, a cell adhesion protein that is upregulated by the WNT1 oncogene… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Familial adenomatous polyposis is an autosomal dominant disorder characterized by the formation of hundreds of… Expand
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Highly Cited
1991
Highly Cited
1991
DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and… Expand
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