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Adenomatous Polyposis Coli

Known as: Colus, Polyposis, Adenomatous Polyposis Colus, Familial Polyposis Syndrome 
An autosomal dominant disorder, characterized by the presence of multiple adenomas in the colon and rectum. It is caused by a germline mutation in… 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Cell polarity is a fundamental property of all cells. In higher eukaryotes, the small GTPase Cdc42, acting through a Par6… 
Highly Cited
2003
Highly Cited
2003
BACKGROUND Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple… 
Review
2001
Review
2001
Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early… 
Review
1996
Highly Cited
1995
Highly Cited
1995
The APC tumor-suppressor protein associates with beta-catenin, a cell adhesion protein that is upregulated by the WNT1 oncogene… 
Highly Cited
1993
Highly Cited
1993
BACKGROUND The current practice of removing adenomatous polyps of the colon and rectum is based on the belief that this will… 
Highly Cited
1993
Highly Cited
1993
A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of… 
Highly Cited
1988
Highly Cited
1988
Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed…