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Top 100 relevant results, sorted by most influential
Enzyme structure and mechanism
- A. Fersht
This is the second edition of this biological reference aimed at undergraduates and graduates. The book covers the structure and mechanism of enzymes, creating a guide to the current understanding of… Expand
Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding
- A. Fersht
- 15 September 1998
The three-dimensional structure of proteins chemical catalysis the basic equations of enzyme kinetics measurement and magnitude of enzymatic rate constants the pH dependence of enzyme catalysis… Expand
Structural biology of the tumor suppressor p53.
The tumor suppressor protein p53 induces or represses the expression of a variety of target genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or other cellular… Expand
Awakening guardian angels: drugging the p53 pathway
- Christopher J. Brown, Sonia Laín, C. Verma, A. Fersht, D. Lane
- Biology, Medicine
- Nature Reviews Cancer
- 1 December 2009
Currently, around 11 million people are living with a tumour that contains an inactivating mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours in which the p53… Expand
The structure of the transition state for folding of chymotrypsin inhibitor 2 analysed by protein engineering methods: evidence for a nucleation-condensation mechanism for protein folding.
The 64-residue protein chymotrypsin inhibitor 2 (CI2) is a single module of structure. It folds and unfolds as a single co-operative unit by simple two-state kinetics via a single rate determining… Expand
The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding.
The theory, assumptions and limitations are outlined for a simple protein engineering approach to the problem of the stability and pathway of protein folding. It is a general procedure for analysing… Expand
Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles.
The interaction of barnase, an extracellular RNase of Bacillus amylolique-faciens, with its intracellular inhibitor barstar is a suitable paradigm for protein-protein interactions, since the… Expand
Molecular mechanism of the interaction between MDM2 and p53.
- O. Schon, A. Friedler, M. Bycroft, S. Freund, A. Fersht
- Chemistry, Medicine
- Journal of molecular biology
- 25 October 2002
We have investigated the kinetic and thermodynamic basis of the p53-MDM2 interaction using a set of peptides based on residues 15-29 of p53. Wild-type p53 peptide bound MDM2 with a dissociation… Expand
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
The tumour suppressor p53 is mutated in half of all human cancers, most frequently with missense substitutions in its core domain. We present a new assessment of the mutation database based on… Expand