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An actin-like gene can determine cell polarity in bacteria.
Achieving proper polarity is essential for cellular function. In bacteria, cell polarity has been observed by using both morphological and molecular markers; however, no general regulators ofExpand
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The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM
Netrins promote axon outgrowth and turning through DCC/UNC-40 receptors. To characterize Netrin signaling, we generated a gain-of-function UNC-40 molecule, MYR::UNC-40. MYR::UNC-40 causes axonExpand
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MreB Actin-Mediated Segregation of a Specific Region of a Bacterial Chromosome
Faithful chromosome segregation is an essential component of cell division in all organisms. The eukaryotic mitotic machinery uses the cytoskeleton to move specific chromosomal regions. ToExpand
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The bacterial actin MreB rotates, and rotation depends on cell-wall assembly
Bacterial cells possess multiple cytoskeletal proteins involved in a wide range of cellular processes. These cytoskeletal proteins are dynamic, but the driving forces and cellular functions of theseExpand
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Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus.
The actin cytoskeleton represents a key regulator of multiple essential cellular functions in both eukaryotes and prokaryotes. In eukaryotes, these functions depend on the orchestrated dynamics ofExpand
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The metabolic enzyme CTP synthase forms cytoskeletal filaments
Filament-forming cytoskeletal proteins are essential for the structure and organization of all cells. Bacterial homologues of the major eukaryotic cytoskeletal families have now been discovered, butExpand
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Two independent spiral structures control cell shape in Caulobacter.
The actin homolog MreB contributes to bacterial cell shape. Here, we explore the role of the coexpressed MreC protein in Caulobacter and show that it forms a periplasmic spiral that is out of phaseExpand
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Cell shape and cell-wall organization in Gram-negative bacteria
In bacterial cells, the peptidoglycan cell wall is the stress-bearing structure that dictates cell shape. Although many molecular details of the composition and assembly of cell-wall components areExpand
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Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization
Significance Across all kingdoms of life, maintaining the correct cell shape is critical for behaviors such as sensing, motility, surface attachment, and nutrient acquisition. Maintaining properExpand
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Caulobacter chromosome segregation is an ordered multistep process
Despite its fundamental nature, bacterial chromosome segregation remains poorly understood. Viewing segregation as a single process caused multiple proposed mechanisms to appear in conflict andExpand
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