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Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche
Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire blood system. We generated a highly specific transgenic reporter of HSPCs in zebrafish. This allowed us toExpand
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UNC-6 (Netrin) Orients the Invasive Membrane of the Anchor Cell in C. elegans
Despite their profound importance in the development of cancer, the extracellular cues that target cell invasion through basement membrane barriers remain poorly understood. A central obstacle hasExpand
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The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo
Localized activation of netrin signaling induces focused F-actin formation and the protrusive force necessary for physical displacement of basement membrane during cell transmigration.
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Traversing the basement membrane in vivo: A diversity of strategies
The basement membrane is a dense, highly cross-linked, sheet-like extracellular matrix that underlies all epithelia and endothelia in multicellular animals. During development, leukocyte trafficking,Expand
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Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.
Integrin expression and activity have been strongly correlated with developmental and pathological processes involving cell invasion through basement membranes. The role of integrins in mediatingExpand
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UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity
Stabilization of oscillatory UNC-40 clustering by its ligand UNC-6 directs localized F-actin generation and polarization of cells.
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Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans
Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. Though never followed directly in vivo, basement membrane dissolution or reducedExpand
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A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation
Invadopodia are specialized membrane protrusions composed of F-actin, actin regulators, signaling proteins, and a dynamically trafficked invadopodial membrane that drive cell invasion throughExpand
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CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment
The microenvironment is an important regulator of hematopoietic stem and progenitor cell (HSPC) biology. Recent advances marking fluorescent HSPCs have allowed exquisite visualization of HSPCs in theExpand
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A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
Visualizing the beginnings of melanoma In cancer biology, a tumor begins from a single cell within a group of precancerous cells that share genetic mutations. Kaufman et al. used a zebrafish melanomaExpand
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