• Publications
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Neurotrophins as synaptic modulators
  • M. Poo
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 2001
The role of neurotrophins as regulatory factors that mediate the differentiation and survival of neurons has been well described. More recent evidence indicates that neurotrophins may also act asExpand
  • 1,699
  • 92
Synaptic modification by correlated activity: Hebb's postulate revisited.
  • G. Bi, M. Poo
  • Psychology, Medicine
  • Annual review of neuroscience
  • 2001
Correlated spiking of pre- and postsynaptic neurons can result in strengthening or weakening of synapses, depending on the temporal order of spiking. Recent findings indicate that there are narrowExpand
  • 1,254
  • 89
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Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action andExpand
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Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates
In Drosophila, plexin A is a functional receptor for semaphorin-1a. Here we show that the human plexin gene family comprises at least nine members in four subfamilies. Plexin-B1 is a receptor for theExpand
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Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses
Activity-induced modification of neuronal connections is essential for the development of the nervous system and may also underlie learning and memory functions of mature brain. Previous studies haveExpand
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  • 66
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Calcium stores regulate the polarity and input specificity of synaptic modification
Activity-induced synaptic modification is essential for the development and plasticity of the nervous system. Repetitive correlated activation of pre- and postsynaptic neurons can induce persistentExpand
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Neurotrophin regulation of neural circuit development and function
Brain-derived neurotrophic factor (BDNF) — a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4 — has emerged as a key regulator ofExpand
  • 1,094
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A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion
Netrins are bifunctional: they attract some axons and repel others. Netrin receptors of the Deleted in Colorectal Cancer (DCC) family are implicated in attraction and those of the UNC5 family inExpand
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Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein triggerExpand
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ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression
Extracellular ATP released from axons is known to assist activity-dependent signaling between neurons and Schwann cells in the peripheral nervous system. Here we report that ATP released fromExpand
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