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Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
  • G. Bi, M. Poo
  • Biology, Medicine
  • The Journal of Neuroscience
  • 15 December 1998
TLDR
The results underscore the importance of precise spike timing, synaptic strength, and postsynaptic cell type in the activity-induced modification of central synapses and suggest that Hebb’s rule may need to incorporate a quantitative consideration of spike timing that reflects the narrow and asymmetric window for the induction of synaptic modification. Expand
Neurotrophins as synaptic modulators
  • M. Poo
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 2001
TLDR
By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections. Expand
Synaptic modification by correlated activity: Hebb's postulate revisited.
  • G. Bi, M. Poo
  • Psychology, Medicine
  • Annual review of neuroscience
  • 2001
TLDR
Spike timing-dependent modifications, together with selective spread of synaptic changes, provide a set of cellular mechanisms that are likely to be important for the development and functioning of neural networks. Expand
Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action andExpand
Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses
TLDR
Using two-photon time-lapse imaging of dendritic spines in acute hippocampal slices from neonatal rats, it is found that the induction of long-term depression by low-frequency stimulation is accompanied by a marked shrinkage of spines, which can be reversed by subsequent high- frequencies that induces LTP. Expand
Calcium stores regulate the polarity and input specificity of synaptic modification
TLDR
Reduction of postsynaptic calcium influx by partial blockade of NMDA (N-methyl-d-aspartate) receptors results in a conversion of LTP to LTD and a loss of input specificity normally associated with LTP, with LTD appearing at heterosynaptic inputs. Expand
Neurotrophin regulation of neural circuit development and function
TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review. Expand
A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion
TLDR
Evidence is provided that netrin-1 triggers the formation of a receptor complex of DCC and UNC5 proteins and simultaneously derepresses the interaction between their cytoplasmic domains, thereby converting DCC- mediated attraction to UNC5/DCC-mediated repulsion. Expand
A critical window for cooperation and competition among developing retinotectal synapses
TLDR
Both the initial synaptic strength and the temporal order of activation are critical for heterosynaptic interactions among convergent synaptic inputs during activity-dependent refinement of developing neural networks. Expand
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
TLDR
Cyclic nucleotides can regulate growth cone behaviors and may be targets for designing treatments to alleviate the inhibition of nerve regeneration by repulsive factors. Expand
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