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CYP2A6 wt Allele

Known as: CPA6, CYP2A, CYP2A3 
Human CYP2A6 wild-type allele is located in the vicinity of 19q13.2 and is approximately 7 kb in length. This allele, which encodes cytochrome P450… 
National Institutes of Health

Related topics

Related topics

12 relations
19q13.2Arachidonic Acid Metabolism PathwayCarcinogen MetabolismCytochrome p450 CYP2A6 enzyme

Broader (1)

CYP2A6 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
Highly Cited
2006
Highly Cited
2006
Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
The present study investigated the role of specific human cytochrome P450 (CYP) enzymes in the in vitro metabolism of valproic… 
Highly Cited
2005
Highly Cited
2005
5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6.
A series of 5- and 6-substituted and unsubstituted 3-heteroaromatic analogues of nicotine were synthesized in an effort to… 
Highly Cited
2005
Highly Cited
2005
CYP2A6 AND CYP2B6 ARE INVOLVED IN NORNICOTINE FORMATION FROM NICOTINE IN HUMANS: INTERINDIVIDUAL DIFFERENCES IN THESE CONTRIBUTIONS
Nornicotine is an N-demethylated metabolite of nicotine. In the present study, human cytochrome P450 (P450) isoform(s) involved… 
Highly Cited
1999
Highly Cited
1999
Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
Abstract Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was… 
Highly Cited
1998
Highly Cited
1998
Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells.
Bronchogenic carcinomas arise from bronchial epithelial cells (BECs). Inhalation exposure of BECs to nitrosamines in cigarette… 
Highly Cited
1997
Highly Cited
1997
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine… 
Highly Cited
1996
Highly Cited
1996
Role of human cytochrome P4502A6 in C-oxidation of nicotine.
Nicotine is primarily metabolized to cotinine in humans. In this study, human cytochrome P450 (CYP) isoform involved in cotinine… 
Highly Cited
1996
Highly Cited
1996
Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.
Cytochrome P450 2A3 (CYP2A3) was previously identified in rat lung by cDNA cloning and recently found to be expressed at a high… 
Highly Cited
1991
Highly Cited
1991
The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3.
We have developed a human lymphoblastoid cell line, designated 3A4/Hol, which stably expresses human CYP3A4 cDNA. This cell line… 
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