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CYP2A6 wt Allele

Known as: CPA6, CYP2A, CYP2A3 
Human CYP2A6 wild-type allele is located in the vicinity of 19q13.2 and is approximately 7 kb in length. This allele, which encodes cytochrome P450… Expand
National Institutes of Health

Papers overview

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2006
2006
CYP2A6 inactivates nicotine to cotinine and cotinine to 3-hydroxycotinine. We investigated which of plasma nicotine and… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE The liver enzyme cytochrome P450 (CYP) 2A6 is primarily responsible for the metabolism of nicotine… Expand
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2005
2005
Nornicotine is an N-demethylated metabolite of nicotine. In the present study, human cytochrome P450 (P450) isoform(s) involved… Expand
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Highly Cited
2004
Highly Cited
2004
Cytochrome P450 (CYP) 2A6 is a major CYP responsible for the metabolism of nicotine and coumarin in humans. We identified a novel… Expand
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Highly Cited
1999
Highly Cited
1999
Abstract Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was… Expand
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1998
1998
Bronchogenic carcinomas arise from bronchial epithelial cells (BECs). Inhalation exposure of BECs to nitrosamines in cigarette… Expand
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Highly Cited
1997
Highly Cited
1997
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine… Expand
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Highly Cited
1996
Highly Cited
1996
Nicotine is primarily metabolized to cotinine in humans. In this study, human cytochrome P450 (CYP) isoform involved in cotinine… Expand
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1996
1996
Cytochrome P450 2A3 (CYP2A3) was previously identified in rat lung by cDNA cloning and recently found to be expressed at a high… Expand
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1991
1991
We have developed a human lymphoblastoid cell line, designated 3A4/Hol, which stably expresses human CYP3A4 cDNA. This cell line… Expand
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