Cytochrome p450 CYP2A6 enzyme

Known as: Cytochrome P 450 CYP2A6, Cytochrome P 450 CYP 2A3, Coumarin 7 Hydroxylase 
Cytochrome P450 2A6 (494 aa, ~57 kDa) is encoded by the human CYP2A6 gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE The liver enzyme cytochrome P450 (CYP) 2A6 is primarily responsible for the metabolism of nicotine… (More)
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Highly Cited
2005
Highly Cited
2005
Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco… (More)
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Highly Cited
2004
Highly Cited
2004
The measurement of the effect of new chemical entities on human cytochrome P450 marker activities using in vitro experimentation… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Nicotine and a variety of other drugs and toxins are metabolized by cytochrome P450 (CYP) 2A6. Our objective was to… (More)
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Highly Cited
2002
Highly Cited
2002
Drug oxidation activities of 12 recombinant human cytochrome P450s (P450) coexpressed with human NADPH-P450 reductase (NPR) in… (More)
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Review
2000
Review
2000
Coumarin 7-hydroxylation is catalysed by a high-affinity CYP2A6 enzyme in human liver microsomes. CYP2A6 is the only enzyme… (More)
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Highly Cited
1999
Highly Cited
1999
Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was investigated… (More)
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Highly Cited
1996
Highly Cited
1996
Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism… (More)
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Highly Cited
1996
Highly Cited
1996
The stability of cytochrome P450 enzymes, cytochrome b5, and NADPH-cytochrome c reductase was examined in (A) human liver samples… (More)
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