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Cytochrome p450 CYP2A6 enzyme

Known as: Cytochrome P 450 CYP2A6, Cytochrome P 450 CYP 2A3, Coumarin 7 Hydroxylase 
Cytochrome P450 2A6 (494 aa, ~57 kDa) is encoded by the human CYP2A6 gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

Related topics

Related topics

19 relations
CYP2A6 geneCYP2A6 wt AlleleCytochrome p450 CYP2B6 enzymeEndoplasmic Reticulum

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Novel human CYP2A6 alleles confound gene deletion analysis
2002
2002
Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma
Cytochrome P450 (CYP) 2A6 and CYP2E1 are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3… 
Highly Cited
1999
Highly Cited
1999
Expression of cytochrome P450 2A6 in Escherichia coli: purification, spectral and catalytic characterization, and preparation of polyclonal antibodies.
Cytochrome P450 (CYP) 2A6 is the principal human enzyme catalyzing coumarin 7-hydroxylation and is known to be involved in the… 
1999
1999
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow.
To choose a sensitive protocol to discriminate populations exposed and not exposed to inducers, five urinary metabolite ratios… 
Review
1998
Review
1998
Clinical importance of non‐genetic and genetic cytochrome P450 function tests in liver disease
Liver disease is associated with reduced metabolic capacity for drugs that are metabolized by oxidative biotransformation. Three… 
Highly Cited
1994
Highly Cited
1994
Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells.
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) is a potential human carcinogen that is… 
Highly Cited
1989
Highly Cited
1989
Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.
Highly Cited
1985
Highly Cited
1985
Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice.
Pyrazole, was given to DBA/2N (D2), C57BL/6N (B6) and AKR/N mice to study its effects on hepatic drug metabolism. A decrease in… 
Highly Cited
1983
Highly Cited
1983
Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.
Highly Cited
1979
Highly Cited
1979
Genetic regulation of coumarin hydroxylase activity in mice. Biochemical characterization of the enzyme from two inbred strains and their F1 hybrid.
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