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Cytochrome p450 CYP2A6 enzyme

Known as: Cytochrome P 450 CYP2A6, Cytochrome P 450 CYP 2A3, Coumarin 7 Hydroxylase 
Cytochrome P450 2A6 (494 aa, ~57 kDa) is encoded by the human CYP2A6 gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

Related topics

Related topics

19 relations
CYP2A6 geneCYP2A6 wt AlleleCytochrome p450 CYP2B6 enzymeEndoplasmic Reticulum

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General
Highly Cited
2010
Highly Cited
2010
Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior
Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of… 
Review
2005
Review
2005
Metabolism and Disposition Kinetics of Nicotine
Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for… 
Highly Cited
2005
Highly Cited
2005
Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco… 
Highly Cited
2004
Highly Cited
2004
Validated assays for human cytochrome P450 activities.
The measurement of the effect of new chemical entities on human cytochrome P450 marker activities using in vitro experimentation… 
Review
2004
Review
2004
Cytochrome P450 gene polymorphism and cancer.
Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and environmental chemicals. Several CYP enzymes… 
Review
2003
Review
2003
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.
Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in target tissue metabolic activation of… 
Highly Cited
1997
Highly Cited
1997
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine… 
Highly Cited
1996
Highly Cited
1996
Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity.
The stability of cytochrome P450 enzymes, cytochrome b5, and NADPH-cytochrome c reductase was examined in (A) human liver samples… 
Highly Cited
1993
Highly Cited
1993
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved in hydroxylation leading to activation of… 
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