• Publications
  • Influence
Metabolism and Disposition Kinetics of Nicotine
TLDR
Current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential therapeutic agents are reviewed. Expand
Nicotine chemistry, metabolism, kinetics and biomarkers.
TLDR
The current optimal plasma cotinine cut-point to distinguish smokers from non-smokers in the general US population is 3 ng ml(-1), which is much lower than that established 20 years ago, reflecting less secondhand smoke exposure due to clear air policies and more light or occasional smoking. Expand
Cotinine as a biomarker of environmental tobacco smoke exposure.
TLDR
A biomarker is desirable in quantitating systemic exposure both in smokers and nonsmokers to constituents of tobacco smoke to reflect exposure to toxic constituents of smoke that are of concern. Expand
Guidelines on nicotine dose selection for in vivo research
TLDR
A new, experimentally based compilation of species-specific dose selection for studies on the in vivo effects of nicotine, addressing issues related to genetic background, age, acute vs chronic exposure, route of administration, and behavioral responses is provided. Expand
Levels of selected carcinogens and toxicants in vapour from electronic cigarettes
TLDR
The findings of this study are consistent with the idea that substituting tobacco cigarettes with e-cigarettes may substantially reduce exposure to selected tobacco-specific toxicants. Expand
From the Food and Drug Administration.
After an initial reading and a rereading of the FDA’s white paper, “Innovation Stagnation Challenge and Opportunity on the Critical Path to New Medical Products” and a thoughtful reading of theExpand
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.
  • N. Benowitz
  • Medicine
  • Annual review of pharmacology and toxicology
  • 6 January 2009
TLDR
Genetic studies indicate roles for nicotinic receptor subtypes, as well as genes involved in neuroplasticity and learning, in development of dependence, and Pharmacotherapeutic approaches to tobacco addiction include nicotine replacement, bupropion, and varenicline. Expand
Pharmacology of nicotine: addiction and therapeutics.
  • N. Benowitz
  • Medicine
  • Annual review of pharmacology and toxicology
  • 1996
Nicotine maintains tobacco addiction and has therapeutic utility to aid smoking cessation and possibly to treat other medical diseases. Nicotine acts on nicotinic cholinergic receptors, whichExpand
Biochemical verification of tobacco use and cessation.
Nicotine addiction.
TLDR
Nicotine acts on nicotinic cholinergic receptors, which demonstrate diversity in subunit structure, function, and distribution in the nervous system, mediating the multiple actions of nicotine described in tobacco users. Expand
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