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CYP2A6 gene

Known as: Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 Gene, CPA6, cytochrome P450 family 2 subfamily A member 6 
This gene plays a role in the oxidation of nicotine to its carcinogenic metabolites.
National Institutes of Health

Related topics

Related topics

10 relations
CYP2A13 geneCYP2A7 geneCYP2B6 geneCarcinogen Metabolism

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CYP2A6 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI
Highly Cited
2006
Highly Cited
2006
Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
We investigated the effect of slow metabolism of nicotine, predicted by CYP2A6 genotypes resulting in ⩽50% activity, on baseline… 
Highly Cited
2006
Highly Cited
2006
CYP2A6 Genotype, Phenotype, and the Use of Nicotine Metabolites as Biomarkers during Ad libitum Smoking
CYP2A6 inactivates nicotine to cotinine and cotinine to 3-hydroxycotinine. We investigated which of plasma nicotine and… 
Review
2005
Review
2005
Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence
Highly Cited
2005
Highly Cited
2005
Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence
To conduct a pharmacogenetic investigation of nicotine metabolism in twins. One hundred and thirty nine twin pairs [110… 
Highly Cited
2004
Highly Cited
2004
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.
Genetically variable CYP2A6 is the primary enzyme that inactivates nicotine to cotinine. Our objective was to investigate allele… 
Highly Cited
2003
Highly Cited
2003
Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration.
Nicotine metabolism is decreased in smokers compared with nonsmokers, but the mechanism(s) responsible for the slower metabolism… 
Highly Cited
2001
Highly Cited
2001
Nicotine metabolism and CYP2A6 allele frequencies in Koreans.
CYP2A6 is a major catalyst of nicotine metabolism to cotinine. Previously, we demonstrated that the interindividual difference in… 
Highly Cited
1999
Highly Cited
1999
Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
Abstract Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was… 
Highly Cited
1990
Highly Cited
1990
Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.
1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-length clone by oligonucleotide-directed… 
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