Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration.

@article{Schoedel2003DownregulationOH,
  title={Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration.},
  author={Kerri Alexandra Schoedel and Edward M. Sellers and Roberta M Palmour and Rachel F. Tyndale},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 1},
  pages={96-104}
}
Nicotine metabolism is decreased in smokers compared with nonsmokers, but the mechanism(s) responsible for the slower metabolism are unknown. Nicotine is inactivated to cotinine by CYP2A6 in human liver [nicotine C-oxidation (NCO)]. CYP2B6 also metabolizes nicotine to cotinine but with lower affinity than CYP2A6. To evaluate the effects of long-term nicotine treatment on hepatic levels of CYP2A6 and CYP2B6, and nicotine metabolism, an African green monkey (AGM) model was developed. As in humans… CONTINUE READING
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Cytochrome P450

  • Y Ramamoorthy, RF Tyndale, EM Sellers
  • 2001
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