• Publications
  • Influence
Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar).
TLDR
A shortened 10-item scale for clinical quantitation of the severity of the alcohol withdrawal syndrome has been developed and can be incorporated into the usual clinical care of patients undergoing alcohol withdrawal and into clinical drug trials of alcohol withdrawal. Expand
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.
TLDR
The data indicate that nicotine metabolism is highly variable among individual livers and that this is due to variable expression of CYP2A6, not CyP2D6. Expand
Venlafaxine oxidation in vitro is catalysed by CYP2D6.
TLDR
In vitro findings predict phenotypic differences in the kinetics of venlafaxine in vivo, although the clinical importance of this is unclear as O-demethylvenlafxine is pharmacologically similar to the parent drug. Expand
Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study
Background There is increasing support for the hypothesis that gonadal steroids involved in the regulation of the human menstrual cycle modulate γ-aminobutyric acid (GABA) neuronal function. ThisExpand
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.
TLDR
It is demonstrated that slow nicotine inactivators are less likely to be adult smokers (dependent or non-dependent) and had an earlier age of first smoking (only dependent smokers). Expand
Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro.
TLDR
Tranylcypromine [particularly R-(+) isomer], tryptamine, and methoxsalen are specific and relatively selective for CYP2A6 and may be useful in vivo to decrease smoking by inhibiting nicotine metabolism with a low risk of metabolic drug interactions. Expand
Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking.
TLDR
It is found that individuals who are nicotine-dependent and have defective CYP2A6 alleles smoked fewer cigarettes per day than those homozygous for wild-type alleles and those with the newly identified CYP 2A6 gene duplication, and the phenotype, as determined by plasma nicotine/cotinine ratios, had a descending rank order for three genotype groups that did not reach significance. Expand
Inhibition of cytochromes P450 by antifungal imidazole derivatives.
TLDR
Ketoconazole seemed to be the most selective for CYP3A4, although it also inhibited CYP2C9, and five antifungal agents that include an imidazole moiety were examined, likely to result in significant drug-drug interactions in vivo. Expand
An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles.
  • C. Xu, Y. Rao, +4 authors R. Tyndale
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 11 January 2002
TLDR
This study identifies, at relatively high frequency in Asians, an allele with decreased activity, a fully functional allele, and an allele containing both substitutions in which function is dramatically reduced. Expand
Interactions of amphetamine analogs with human liver CYP2D6.
TLDR
It is suggested that phenylisopropylamines as a class interact with CYP2D6 as substrates and/or inhibitors, and the potential for polymorphic oxidation via CYP 2D6 may be a source of interindividual variation in their abuse liability and toxicity. Expand
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