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  • Influence
BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes.
OBJECTIVES To identify predictors of utilization of breast-ovarian cancer susceptibility (BRCA1 gene) testing and to evaluate outcomes of participation in a testing program. DESIGN ProspectiveExpand
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A brief assessment of concerns associated with genetic testing for cancer: the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire.
The Multidimensional Impact of Cancer Risk Assessment (MICRA) is a new tool to measure the specific impact of result disclosure after genetic testing. The authors compared its performance with thatExpand
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Attitudes about genetic testing for breast-ovarian cancer susceptibility.
PURPOSE In anticipation of the availability of genetic testing for a breast-ovarian cancer susceptibility gene (BRCA1), this study examined interest in and expectations about the impact of aExpand
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Prophylactic surgery decisions and surveillance practices one year following BRCA1/2 testing.
BACKGROUND Although genetic testing for breast cancer risk is clinically available, its impact on health-related behaviors is unknown. This study examined prophylactic surgery and surveillanceExpand
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Ethnic differences in knowledge and attitudes about BRCA1 testing in women at increased risk.
Informed consent for BRCA1 mutation testing will require adequate knowledge of patterns of inheritance of cancer and the benefits, limitations, and risks of DNA testing. This study examined knowledgeExpand
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Genetic testing for a BRCA1 mutation: Prophylactic surgery and screening behavior in women 2 years post testing
Mutations in the BRCA1 gene are associated with an increased risk of breast and ovarian cancer in carrier women. An understanding of behavioral responses to BRCA1 mutation testing by mutationExpand
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Neural Substrates of Abstinence-Induced Cigarette Cravings in Chronic Smokers
Craving is a hallmark of drug dependence, including dependence on nicotine. Many studies have examined the neural substrates of cravings elicited by smoking-related cues. Less is known about theExpand
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BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes.
PURPOSE To compare genetic test results for deleterious mutations of BRCA1 and BRCA2 with estimated probabilities of carrying such mutations; to assess sensitivity of genetic testing; and to assessExpand
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Controlled trial of pretest education approaches to enhance informed decision-making for BRCA1 gene testing.
BACKGROUND In response to the isolation of the BRCA1 gene, a breast-ovarian cancer-susceptibility gene, biotechnology companies are already marketing genetic tests to health care providers and to theExpand
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Anticipated uptake and impact of genetic testing in hereditary breast and ovarian cancer families.
In anticipation of the identification of the BRCA1 gene, we studied the interest in and anticipated reaction to DNA testing for mutations in this gene in members of high-risk families. We surveyed 91Expand
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