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Arylamine N-Acetyltransferase

Known as: Acetyl-CoA Arylamine N-Acetyltransferase, Arylamine N Acetyltransferase, Acetyl-CoA:arylamine N-acetyltransferase 
An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without… 
National Institutes of Health

Related topics

Related topics

14 relations
In BloodN-hydroxyarylamine O-acetyltransferaseNAT1 geneNAT2 gene

Narrower (2)

N-acetyltransferase 1NAT2 protein, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Photoelectron spectroscopic study of the electronic band structure of polyfluorene and fluorene-arylamine copolymers at interfaces
The occupied and unoccupied states of poly(9,9‘-dioctylfluorene) (F8) and poly(9,9‘-dioctylfluorene-co-bis-N,N‘-(4-butylphenyl… 
Highly Cited
2005
Highly Cited
2005
Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines.
The NATs (arylamine N-acetyltransferases) are a well documented family of enzymes found in both prokaryotes and eukaryotes. NATs… 
Highly Cited
2004
Highly Cited
2004
Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies.
Arylamine N-acetyltransferases (NATs) catalyze an acetyl group transfer from acetyl coenzyme A (AcCoA) to arylamines, hydrazines… 
Review
2000
Review
2000
An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes.
Arylamine N:-acetyltransferase (NAT) was first identified as the inactivator of the anti-tubercular drug isoniazid. The enzyme… 
Highly Cited
1994
Highly Cited
1994
Activation of 2‐Hydroxyamino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridne by cDNA‐expressed Human and Rat Arylsulfotransferases
Sulfation plays an obligatory role in the activation of N‐hydroxy derivatives of carcinogenic aryl‐amiric(amide)s and… 
1991
1991
Functionalized membrane supports for covalent protein microsequence analysis.
Highly Cited
1990
Highly Cited
1990
Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.
1986
1986
N-hydroxyarylamine O-acetyltransferase in hamster liver: identity with arylhydroxamic acid N,O-acetyltransferase and arylamine N-acetyltransferase.
N-Hydroxyarylamine O-acetyltransferase, arylhydroxamic acid N,O-acetyltransferase, and arylamine N-acetyltransferase in hamster… 
Highly Cited
1985
Highly Cited
1985
DNA adducts formed from the probable proximate carcinogen, N-hydroxy-3,2' -dimethyl-4-aminobiphenyl, by acid catalysis or S-acetyl coenzyme A-dependent enzymatic esterification.
The arylamine carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMABP) has been proposed to be metabolically activated to DNA-binding… 
Highly Cited
1957
Highly Cited
1957
The biochemistry of aromatic amines. II. The conversion of arylamines into arylsulphamic acids and arylamine-N-glucosiduronic acids.
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