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Arylamine N-Acetyltransferase

Known as: Acetyl-CoA Arylamine N-Acetyltransferase, Arylamine N Acetyltransferase, Acetyl-CoA:arylamine N-acetyltransferase 
An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without… Expand
National Institutes of Health

Related topics

Related topics

14 relations
In BloodN-hydroxyarylamine O-acetyltransferaseNAT1 geneNAT2 gene
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Narrower (2)

N-acetyltransferase 1NAT2 protein, human

Papers overview

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Highly Cited
2013
Highly Cited
2013
Efficient inorganic-organic hybrid perovskite solar cells based on pyrene arylamine derivatives as hole-transporting materials.
A set of three N,N-di-p-methoxyphenylamine-substituted pyrene derivatives have successfully been synthesized and characterized by… Expand
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Highly Cited
2003
Highly Cited
2003
Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro.
Comparative two-dimensional proteome analysis was used to identify proteins differentially expressed in multiple clinical normal… Expand
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Review
2000
Review
2000
An update on genetic, structural and functional studies of arylamine N-acetyltransferases in eucaryotes and procaryotes.
Arylamine N:-acetyltransferase (NAT) was first identified as the inactivator of the anti-tubercular drug isoniazid. The enzyme… Expand
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Highly Cited
2000
Highly Cited
2000
Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells.
Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely distributed throughout the body. In… Expand
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Highly Cited
1998
Highly Cited
1998
Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium between NAT1*10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NAT1 and NAT2.
The study of placental xenobiotic metabolism is important for the determination of foetal exposure to environmental chemicals as… Expand
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Highly Cited
1995
Highly Cited
1995
Palladium-catalyzed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents
Abstract The reaction of aryl halides with secondary amines in the presence of silylamide base and tri- o -tolyphopshine… Expand
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Highly Cited
1994
Highly Cited
1994
Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.
The metabolic activation of food-borne heterocyclic amines to colon carcinogens in humans is hypothesized to occur via N… Expand
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Highly Cited
1990
Highly Cited
1990
Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.
To elucidate the molecular basis of human N-acetylation polymorphism, cDNA clones encoding human liver N-acetyltransferases (EC 2… Expand
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Highly Cited
1983
Highly Cited
1983
Arylamine-DNA adducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcinogenesis
Hepatic N-oxidation, followed by N-glucuronidation, has been proposed as a route of metabolic activation for arylamine bladder… Expand
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Highly Cited
1980
Highly Cited
1980
Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activity.
  • H. Hamm, M. Menaker
  • Proceedings of the National Academy of Sciences…
  • 1980
    • Corpus ID: 6510965
There is a large-amplitude circadian rhythm of indoleamine metabolism in the retina-pigment epithelium of the chicken. N… Expand
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