Arylamine N-Acetyltransferase

Known as: Acetyl-CoA Arylamine N-Acetyltransferase, Arylamine N Acetyltransferase, Acetyl-CoA:arylamine N-acetyltransferase 
An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without… (More)
National Institutes of Health

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In BloodN-hydroxyarylamine O-acetyltransferaseNAT1 geneNAT2 gene
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N-acetyltransferase 1NAT2 protein, human

Papers overview

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Review
2012
Review
2012
Arylamine N-acetyltransferase 1: a novel drug target in cancer development.
The human arylamine N-acetyltransferases first attracted attention because of their role in drug metabolism. However, much of the… (More)
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2007
2007
Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells.
Human arylamine N-acetyltransferases (NAT) bioactivate arylamine and heterocyclic amine carcinogens present in red meat and… (More)
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2001
2001
Arylamine N-Acetyltransferase from Chicken Liver
  • Takeo DeguchiS, Yasushi SakamotoO, Yukiko SasakiS, Keiichi UyemuraO
  • 2001
Five monoclonal antibodies against arylamine acetyltransferase (EC 2.3.1.5) from the chicken liver were established by immunizing… (More)
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2000
2000
Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells.
Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely distributed throughout the body. In… (More)
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1996
1996
Arylamine N-acetyltransferase in erythrocytes of cystic fibrosis patients.
Sulphamethoxazole, a substrate of human arylamine N-acetyltransferase, is used in the treatment of cystic fibrosis patients, who… (More)
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Highly Cited
1994
Highly Cited
1994
Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.
The metabolic activation of food-borne heterocyclic amines to colon carcinogens in humans is hypothesized to occur via N… (More)
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1993
1993
Human acetylator genotype: Relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol
Polymorphic expression of arylamine N-acetyltransferase (EC 2.3.1.5) may be a differential risk factor in metabolic activation of… (More)
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Highly Cited
1991
Highly Cited
1991
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.
A genetic polymorphism of human liver arylamine N-acetyltransferase (NAT; EC 2.3.1.5) enzyme activity divides populations into… (More)
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Highly Cited
1990
Highly Cited
1990
Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.
To elucidate the molecular basis of human N-acetylation polymorphism, cDNA clones encoding human liver N-acetyltransferases (EC 2… (More)
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1985
1985
New spectrophotometric and radiochemical assays for acetyl-CoA: arylamine N-acetyltransferase applicable to a variety of arylamines.
Simple and sensitive spectrophotometric and radiochemical procedures are described for the assay of acetyl-CoA:arylamine N… (More)
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