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Comparison of iron‐catalyzed DNA and lipid oxidation
TLDR
In this liposome system, sufficient peroxide from either within the lipid or from exogenous sources must be present to generate equimolar iron(II) and iron(III), which is thought to be important for the initation of lipid peroxidation. Expand
Reactivity of propylene oxides towards deoxycytidine and identification of reaction products.
TLDR
While differences in reactivity among the epoxides towards specific nitrogen and oxygen sites were found, total reactivity correlated with Taft sigma-values of the substituent groups. Expand
Characterization and quantitation of 3-alkylthymidines from reactions of mutagenic propylene oxides with thymidine.
TLDR
Formation of 3-alkylthymidines correlated to Taft sigma electron withdrawing values for the substituents on the epoxides and mutagenicities in strain TA100 of the Ames Assay. Expand
Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene.
TLDR
The hypothesis that nitrated pyrenes are metabolized to mutagens through nitroreduction is supported, as in Salmonella the limiting step in the metabolic activation of 1-nitropyrene appears to be the initial reduction to 1-Nitrosopyrene, while with the dinitropyrenes subsequent esterification of the reduced intermediates seems critical. Expand
DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.
TLDR
Nitrated pyrenes are environmental pollutants and potent mutagens in the Salmonella reversion assay and mutation induction by 1-nitropyrene in Chinese hamster ovary (CHO) cells were related to the extent of metabolism and DNA adduct formation. Expand
DNA binding by 1-nitropyrene and 1,6-dinitropyrene in vitro and in vivo: effects of nitroreductase induction.
TLDR
Although nitroreduction is involved in DNA adduct formation by 1,6-dinitropyrene, additional factors (e.g. O-acetylation) limit the extent of DNA binding in vivo. Expand
Metabolism of 2‐acetylaminofluorene in the chinese hamster ovary cell mutation assay
TLDR
Data indicate that CHO cells metabolized N‐hydroxy‐2‐AAF to a reactive derivative by N‐deacetylation to N‐acetoxy‐2-AF, while N‐Hydroxy‐ 2‐AF reacted direcitly with DNA. Expand
Aerobic and anaerobic reduction of nitrated pyrenes in vitro.
TLDR
1,6- and 1,8-dinitropyrene are reduced to a greater extent than 1-nitropyrene and1,3-d initropyrene, which corresponds to their relative biological potencies as mutagens and carcinogens. Expand
Acetyl coenzyme A-dependent binding of carcinogenic and mutagenic dinitropyrenes to DNA.
TLDR
It is suggested that cytosolic nitroreductases catalyze the formation of N-hydroxy arylamine intermediates which in the case of dinitropyrenes are converted to reactive N-acetoxy aryamines by cytOSolic AcCoA-dependent acetylases. Expand
Reactivity of mutagenic propylene oxides with deoxynucleosides and DNA.
TLDR
Correlations for reactivity of the propylene oxides with the individual deoxynucleosides in solution and in DNA, except for dThd, were indicated for mutagenicity in TA100 in the liquid-preincubation Ames test, however, this was not the case for Mutagenicities determined with the plate incorporation procedure nor with TA1535, where the relativemutagenicity of trichloropropylene oxide was the outstanding difference. Expand
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