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NAT2 gene

Known as: ARYLAMIDE ACETYLASE 2, N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Gene, NAT-2 
This gene plays a role in both the activation and deactivation of xenobiotics.
National Institutes of Health

Related topics

Related topics

8 relations
AcetylationArylalkylamine N-AcetyltransferaseArylamine N-AcetyltransferaseLupus Erythematosus, Systemic

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NAT2 wt Allele

Papers overview

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2020
2020
Genetic variants of N-acetyltransferases 1 and 2 (NAT1 and NAT2) in cynomolgus and rhesus macaques.
2015
2015
Determination of NAT2 acetylation status in the Greenlandic population
N-acetyltransferase 2 (NAT2) is a well-studied phase II xenobiotic metabolizing enzyme relevant in drug metabolism and… 
2008
2008
Systemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic Rat
Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2… 
2006
2006
NAT2 slow acetylation and bladder cancer in workers exposed to benzidine
2006
2006
NAT2 gene polymorphism and sporadic colorectal cancer. Prevalence, tumor stage and prognosis. A preliminary study in 70 patients.
AIM Theoretically, individuals with a NAT2 rapid acetylator genotype are exposed to a higher risk of developing colorectal cancer… 
2005
2005
NAT2*5/*5 Genotype (341T>C) Is a Potential Risk Factor for Schistosomiasis-Associated Bladder Cancer in Egyptians
Arylamine N-acetyl transferase (NAT2) displays extensive genetic polymorphisms that affect the rates of acetylation of drugs and… 
2002
2002
GSTM-1 and NAT2 and genetic alterations in colon tumors
Objective: Phase II metabolizing enzymes such as glutathione S-transferases and N-acetyltransferase are involved in the… 
2001
2001
Active Electronic Arrays for Genotyping of NAT2 Polymorphisms
The N -acetyltransferase 2 ( NAT2) gene is autosomal, dominant, and intronless with an open reading frame of 870 bp. It is… 
Highly Cited
1997
Highly Cited
1997
Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours.
Arylamine N-acetyltransferases (NATs) are encoded at two loci on 8p22, a region subject to deletions in bladder tumours. The two… 
Highly Cited
1995
Highly Cited
1995
Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium.
Heterocyclic aromatic amines formed during the cooking of meat and meat-derived products can be activated to reactive metabolites… 
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