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An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera
A review of the botany, physical and chemical properties, and biological activities of the Aloe vera plant finds that it contains multiple constituents with potential biological and toxicological activities, yet the active components elude definition. Expand
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay.
The tumorigenicity of two coal tar mixtures was compared and indicated that the benzo[a]pyrene in the coal tar diets could be responsible for the forestomach tumors, while the lung and liver tumors appeared to be due to other genotoxic components contained within thecoal tar mixture, whereas the small intestine tumors resulted from chemically-induced cell proliferation that occurred at high doses of coal tar. Expand
Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan
Data is reviewed on the human exposure, environmental fate, efficacy of anti-microbial activity, absorption, distribution, metabolism and elimination, endocrine disrupting effects, and toxicity of triclosan. Expand
DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
DNA adduct formation from AA treatment in adult mice showed a supralinear dose-response relationship, consistent with saturation of oxidative metabolism at higher doses, which increases the understanding of the mutagenic potential of GA and provides further evidence for a genotoxic mechanism in AA carcinogenesis. Expand
DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.
Results provide strong support for a genotoxic mechanism of AA carcinogenicity in rodents and the kinetic/biomarker approaches described here may represent a meaningful way to extrapolate cancer risks to actual human exposures from food, which are much lower. Expand
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
Results show that alterations in the expression of miRNAs are a prominent event during development of NASH induced by methyl deficiency and strongly suggest that severity ofNASH and susceptibility to NASH may be determined by variations in miRNA expression response. Expand
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.
Observations suggest that the plasma levels of miRNAs may be used as biomarkers for noninvasive monitoring the extent of NAFLD-associated liver injury and susceptibility toNAFLD. Expand
Malachite Green: A Toxicological Review
Malachite green, an N-methylated diaminotriphenylmethane dye, is used primarily as a therapeutic agent in aquaculture. In solution, the dye exists as a mixture of the cation (chromatic malachiteExpand
E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
It is demonstrated that microRNA miR‐200 family‐mediated transcriptional up‐regulation of E‐cadherin in mesenchymal MDA‐MB‐231 and BT‐549 cells is associated directly with translational repression of ZEB1 and indirectly with increased acetylation of histone H3 at the E‐ cadheringin promoter. Expand
Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure.
Assessment of the carcinogenicity of acrylamide in male and female B6C3F(1) mice and F344/N rats and previous mechanistic studies provide strong support for the concept that acylamide is activated to a carcinogen through metabolism to glycidamide. Expand