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Adenylate Cyclase

Known as: adenylylcyclase, Cyclases, Adenylyl, Adenylyl Cyclase 
Enzymes of the lyase class that catalyze the formation of CYCLIC AMP and pyrophosphate from ATP.
National Institutes of Health

Related topics

Related topics

21 relations
Adenosine MonophosphateCyclic AMPIn BloodProcess of secretion
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Narrower (10)

Adenylyl Cyclase 9PsiP protein, Zea maysadenylate cyclase 3adenylate cyclase 9
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Broader (2)

LyasePhosphorus-Oxygen Lyases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1998
Review
1998
Dopamine receptors: from structure to function.
The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1… Expand
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Highly Cited
1994
Highly Cited
1994
Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.
Estrogenic hormones, believed to exert most of their effects via the direct interaction of their receptors with chromatin, are… Expand
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Highly Cited
1989
Highly Cited
1989
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells.
A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine… Expand
Highly Cited
1982
Highly Cited
1982
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
  • S. Leppla
  • Proceedings of the National Academy of Sciences…
  • 1982
    • Corpus ID: 20307576
Anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins… Expand
Highly Cited
1982
Highly Cited
1982
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
  • T. Katada, M. Ui
  • Proceedings of the National Academy of Sciences…
  • 1982
    • Corpus ID: 33285877
GTP and isoproterenol activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in washed membranes… Expand
Highly Cited
1981
Highly Cited
1981
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
The diterpene, forskolin [half-maximal effective concentration (EC50), 5-10 microM] activates adenylate cyclase [ATP… Expand
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Highly Cited
1978
Highly Cited
1978
Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.
Treatment of pigeon erythrocyte membranes with cholera toxin and NAD(+) enhanced the GTP stimulation and suppressed the F… Expand
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Highly Cited
1978
Highly Cited
1978
ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.
  • D. Gill, R. Meren
  • Proceedings of the National Academy of Sciences…
  • 1978
    • Corpus ID: 25453003
In the presence of ATP and a cytosolic factor, cholera toxin fragment A1 catalyzes the transfer of ADP-ribose from NAD to a… Expand
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Highly Cited
1975
Highly Cited
1975
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the… Expand
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Highly Cited
1974
Highly Cited
1974
A highly sensitive adenylate cyclase assay.
Abstract A highly sensitive adenylate cyclase assay method has been developed which employs sequential chromatography on columns… Expand
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