Adenylate Cyclase

Known as: adenylylcyclase, Cyclases, Adenylyl, Adenylyl Cyclase 
Enzymes of the lyase class that catalyze the formation of CYCLIC AMP and pyrophosphate from ATP.
National Institutes of Health

Related topics

Related topics

20 relations
Adenosine MonophosphateCyclic AMPIn BloodProcess of secretion
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Narrower (9)

Adenylyl Cyclase 9adenylate cyclase 3adenylate cyclase 9adenylyl cyclase 1
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Broader (2)

LyasePhosphorus-Oxygen Lyases

Papers overview

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Highly Cited
2003
Highly Cited
2003
Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway.
Type III secretion systems (TTSSs) are utilized by numerous bacterial pathogens to inject effector proteins directly into host… (More)
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Review
2000
Review
2000
The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily.
The pituitary adenylate cyclase-activating polypeptide (PACAP)/ glucagon superfamily includes nine hormones in humans that are… (More)
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Highly Cited
1994
Highly Cited
1994
Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.
Estrogenic hormones, believed to exert most of their effects via the direct interaction of their receptors with chromatin, are… (More)
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Highly Cited
1994
Highly Cited
1994
Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells.
Pathogenic bacteria of the genus Yersinia release in vitro a set of antihost proteins called Yops. Upon infection of cultured… (More)
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Highly Cited
1985
Highly Cited
1985
Odorant-sensitive adenylate cyclase may mediate olfactory reception
The mechanism of the sense of smell has long been a subject for theory and speculation1–5. More recently, the notion of odorant… (More)
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Highly Cited
1982
Highly Cited
1982
Phagocyte impotence caused by an invasive bacterial adenylate cyclase.
For unknown reasons, humans infected with the bacterium Bordetella pertussis are exceptionally vulnerable to secondary infections… (More)
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Highly Cited
1982
Highly Cited
1982
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.
Activation of the purified guanine nucleotide-binding regulatory component (G/F) of adenylate cyclase by F- requires the presence… (More)
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Highly Cited
1981
Highly Cited
1981
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
The diterpene, forskolin [half-maximal effective concentration (EC50), 5-10 microM] activates adenylate cyclase [ATP… (More)
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Highly Cited
1975
Highly Cited
1975
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the… (More)
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Highly Cited
1974
Highly Cited
1974
A highly sensitive adenylate cyclase assay.
A highly sensitive adenylate cyclase assay method has been developed which employs sequential chromatography on columns of Dowex… (More)
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