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Adenylate Cyclase

Known as: adenylylcyclase, Cyclases, Adenylyl, Adenylyl Cyclase 
Enzymes of the lyase class that catalyze the formation of CYCLIC AMP and pyrophosphate from ATP.
National Institutes of Health

Related topics

Related topics

21 relations
Adenosine MonophosphateCyclic AMPIn BloodProcess of secretion

Narrower (10)

Adenylyl Cyclase 9PsiP protein, Zea maysadenylate cyclase 3adenylate cyclase 9

Broader (2)

LyasePhosphorus-Oxygen Lyases

Papers overview

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Highly Cited
2011
Highly Cited
2011
Crystal Structure of the β2Adrenergic Receptor-Gs protein complex
G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as… 
Review
1998
Review
1998
Dopamine receptors: from structure to function.
The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1… 
Highly Cited
1994
Highly Cited
1994
Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.
Estrogenic hormones, believed to exert most of their effects via the direct interaction of their receptors with chromatin, are… 
Highly Cited
1994
Highly Cited
1994
Translocation of a hybrid YopE‐adenylate cyclase from Yersinia enterocolitica into HeLa cells
Pathogenic bacteria of the genus Yersinia release in vitro a set of antihost proteins called Yops. Upon infection of cultured… 
Highly Cited
1989
Highly Cited
1989
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells.
Highly Cited
1982
Highly Cited
1982
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
  • S. Leppla
  • Proceedings of the National Academy of Sciences…
  • 1982
  • Corpus ID: 20307576
Anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins… 
Highly Cited
1982
Highly Cited
1982
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
  • T. KatadaM. Ui
  • Proceedings of the National Academy of Sciences…
  • 1982
  • Corpus ID: 33285877
GTP and isoproterenol activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in washed membranes… 
Highly Cited
1981
Highly Cited
1981
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
The diterpene, forskolin [half-maximal effective concentration (EC50), 5-10 microM] activates adenylate cyclase [ATP… 
Highly Cited
1975
Highly Cited
1975
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the… 
Highly Cited
1974
Highly Cited
1974
A highly sensitive adenylate cyclase assay.
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