ORL1, a novel member of the opioid receptor family

@article{Mollereau1994ORL1AN,
  title={ORL1, a novel member of the opioid receptor family},
  author={Catherine Mollereau and Marc Parmentier and Pierre Mailleux and J. L. Butour and Christiane Moisand and Pascale Chalon and Daniel Caput and Gilbert Vassart and Jean Claude Meunier},
  journal={FEBS Letters},
  year={1994},
  volume={341}
}
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965 Citations
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Molecular characterization and functional expression of opioid receptor-like1 receptor*
TLDR
Stimulation with ORL1 specific agonist, nociceptin/orphanin FQ, increased [35S]GTP γ S binding to SK-N-SH cell membranes, and attenuated, forskolin-stimulated accumulation of cellular cAMP, indicative that activation of OrL1 activates G proteins and inhibits adenylyl cyclase.
Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type
Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
TLDR
Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family
Structure and characterization of the gene encoding a mouse kappa3-related opioid receptor.
Cloning, expression and classification of a kappa3-related opioid receptor using antisense oligodeoxynucleotides
Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor.
  • J. Meunier
  • Biology
    European journal of pharmacology
  • 1997
Cloning, expression and functional role of a nociceptin/orphanin FQ receptor in the porcine gastrointestinal tract.
Receptorphin: A conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells
TLDR
This work identifies, for the first time a peptide, in a receptor sequence, possessing ligand-agonistic activities, derived from the sequence of the second transmembrane loop of the opioid receptor.
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