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Monoclonal antibody to a plasma membrane antigen of neurons.
Results suggest that the antigen is a complex ganglioside in plasma membranes of retina neuron cell bodies but not axons or dendrites, which suggests that antibody A2B5 cytotoxicity against retina cells is inhibited by a GQ gangliosiside fraction from bovine brain but not by other purifiedgangliosides tested. Expand
Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells
This work used RNA interference and a quantitative cultured cell assay to systematically screen functional roles of all kinases and phosphatases and subsequently 43% of predicted Drosophila genes were identified as Hh pathway components. Expand
Release factors differing in specificity for terminator codons.
In a previous paper, initiator and terminator trinucleotides were shown to stimulate sequentially the binding of f-Met-tRNA to ribosomes and the release of free f-methionine from the ribosomalExpand
Drosophila NK-homeobox genes.
  • Y. Kim, M. Nirenberg
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 October 1989
Four Drosophila melanogaster homeobox genes were found by screening a genomic DNA library with oligodeoxynucleotides that correspond to a conserved amino acid sequence that is part of the putative ofExpand
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
The coupled inhibitory and positive regulatory mechanisms for adenylate cyclase provide a means of activating and deactivating neural circuits hours after the initial event and thus may play a role in a memory process. Expand
The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides
A stable cell-free system has been obtained from E. coli which incorporates C14-valine into protein at a rapid rate, and a requirement for template RNA is described, needed for amino acid incorporation even in the presence of soluble RNA and ribosomes. Expand
Neurotransmitter Synthesis by Neuroblastoma Clones
The results show that genes determining neurotransmitter species can be expressed in dividing cells, that the parental programs of gene expression are inherited, and that dividing cells can be programmed with respect to their ability to communicate with other cells. Expand
Synapse formation between clonal neuroblastoma X glioma hybrid cells and striated muscle cells.
Clonal neuroblastoma X glioma hybrid cells were shown to form synapses with cultured, striated muscle cells, similar to those of the normal, neuromuscular synapse at an early stage of development. Expand
Structure and evolution of four POU domain genes expressed in mouse brain.
The absence of introns from the coding regions of the four Pou domain genes and the similarity of amino acid sequences of the corresponding proteins suggest that the coding region of the ancestral class III POU domain gene lacked introns and therefore may have originated by reverse transcription of a molecule of POUdomain mRNA followed by insertion of the cDNA into germ cell genomic DNA. Expand