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Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
A fundamental role of glutathione in the body may be to protect tissues against electrophilic attack by drug metabolites and other alkylating agents. Expand
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
It is proposed thatacetaminophen-induced hepatic necrosis is mediated by a toxic metabolite of acetaminophen, which inhibits synthesis of cytochrome P-450 and thereby prevented the hepatic damage. Expand
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
It is proposed that acetaminophen-induced hepatic necrosis may be caused by the covalent binding of a chemically reactive metabolite to vital hepatsic macromolecules. Expand
A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity.
The simplified but precise method described in this paper involves treatment of the serum with alcoholic potassium hydroxide to liberate the cholesterol from the lipoprotein complexes and to saponify the cholesterol esters. Expand
Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines.
In the rabbit hypothalamus, NE is formed five times more rapidly than in the midbrain, though the turnover times are almost identical, which suggests that the rate of synthesis might be similar in each adrenergic unit and that variations in rates of synthesis in different brain areas are a function of the number of neurons per gram of tissue. Expand
Role of sodium, potassium, ouabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes.
Na+ is essential for the process that stores and accumulates NE and 5HT and that in synaptosomes the action of Na+ is inhibited by K+. Expand
Absorption of drugs from the rat small intestine.
The relative rates of absorption of a large number of drugs have been measured by perfusing solutions of drugs through the entire small intestine of the anesthetized rat and the degree of ionization of an organic electrolyte in solution appears to be one of the most important factors determining its absorption from the rat small intestine. Expand
The Pharmacological Basis for the Rational Use of Atabrine in the Treatment of Malaria.
The important factors which are concerned with the physiological disposition of atabrine have been defined and the practical importance of the above factors has been examined by a study of the plasmaAtabrine concentrations achieved in groups of individuals on various regimes of supressive and definitive therapy. Expand
On the mechanism of intestinal absorption of drugs.
The intestinal absorption of acidic drugs is decreased severalfold and the absorption of basic drugs increased severalfold when the pH of the intestinal contents is raised from 4 to 8. This supportsExpand