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Transduction of Receptor Signals by ß-Arrestins
The transmission of extracellular signals to the interior of the cell is a function of plasma membrane receptors, of which the seven transmembrane receptor family is by far the largest and mostExpand
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Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
Many of the G-protein-coupled receptors for hormones that bind to the cell surface can signal to the interior of the cell through several different classes of G protein. For example, although most ofExpand
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An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
Dopamine plays an important role in the etiology of schizophrenia, and D2 class dopamine receptors are the best-established target of antipsychotic drugs. Here we show that D2 class-receptor-mediatedExpand
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Signalling: Seven-transmembrane receptors
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findingsExpand
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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
We have replaced the C-terminal portion of the third intracellular loop of the beta 2-adrenergic receptor (residues 266-272) with the homologous region of the alpha 1B-adrenergic receptor. In aExpand
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Beta-arrestins and cell signaling.
Upon their discovery, beta-arrestins 1 and 2 were named for their capacity to sterically hinder the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately resulting inExpand
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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
beta-Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR) desensitization, also function in internalization and signaling ofExpand
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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
beta-Arrestins are versatile adapter proteins that form complexes with most G-protein-coupled receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein-coupledExpand
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Seven-transmembrane-spanning receptors and heart function
Understanding precisely how the heart can recognize and respond to many different extracellular signalling molecules, such as neurotransmitters, hormones and growth factors, will aid theExpand
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Desensitization of G protein-coupled receptors and neuronal functions.
G protein-coupled receptors (GPCRs) have proven to be the most highly favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are expressed in the brain, where they playExpand
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