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Transduction of Receptor Signals by ß-Arrestins
The transmission of extracellular signals to the interior of the cell is a function of plasma membrane receptors, of which the seven transmembrane receptor family is by far the largest and most… Expand
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
A mechanism previously shown to mediate uncoupling of the β2-adrenergic receptor from Gs and thus heterologous desensitization (PKA-mediated receptor phosphorylation), also serves to ‘switch’ coupling of this receptor fromGs to Gi and initiate a new set of signalling events. Expand
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
- J. Beaulieu, T. Sotnikova, S. Marion, R. Lefkowitz, R. Gainetdinov, M. Caron
- Medicine, Biology
- 29 July 2005
It is demonstrated that, apart from its classical function in receptor desensitization, beta-arrestin 2 also acts as a signaling intermediate through a kinase/phosphatase scaffold, thus implicating beta-arsenin 2 as a positive mediator of dopaminergic synaptic transmission and a potential pharmacological target for dopamine-related psychiatric disorders. Expand
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
- P. Samama, S. Cotecchia, T. Costa, R. Lefkowitz
- Medicine, Biology
- The Journal of biological chemistry
- 5 March 1993
The experimental findings with the mutant receptor cannot be adequately rationalized within the theoretical framework of the Ternary Complex Model, and an extended version of this model that includes an explicit isomerization of the receptor to an active state closely models all the findings for both the mutant and the wild-type receptors. Expand
Signalling: Seven-transmembrane receptors
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings… Expand
Beta-arrestins and cell signaling.
- S. Dewire, Seungkirl Ahn, R. Lefkowitz, S. Shenoy
- Biology, Medicine
- Annual review of physiology
- 16 February 2007
The signaling capacities of these versatile adapter molecules are reviewed and the possible implications for cellular processes such as chemotaxis and apoptosis are discussed. Expand
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
beta-Arrestins are versatile adapter proteins that form complexes with most G-protein-coupled receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein-coupled… Expand
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
beta-Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR) desensitization, also function in internalization and signaling of… Expand
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Data suggest that beta-arrestin binding, which terminates receptor-G protein coupling, also initiates a second wave of signal transduction in which the "desensitized" receptor functions as a critical structural component of a mitogenic signaling complex. Expand
Desensitization of G protein-coupled receptors and neuronal functions.
- R. Gainetdinov, R. Premont, L. Bohn, R. Lefkowitz, M. Caron
- Psychology, Medicine
- Annual review of neuroscience
- 24 June 2004
An important and specific role of GRKs and beta arrestins in regulating physiological responsiveness to psychostimulants and morphine suggests potential involvement of these molecules in certain brain disorders, such as addiction, Parkinson's disease, mood disorders, and schizophrenia. Expand