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Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
TLDR
In patients with advanced heart failure and a prolonged QRS interval, cardiac-resynchronization therapy decreases the combined risk of death from any cause or first hospitalization and, when combined with an implantable defibrillator, significantly reduces mortality. Expand
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group.
TLDR
Carvedilol reduces the risk or death as well as the risk of hospitalization for cardiovascular causes in patients with heart failure who are receiving treatment with digoxin, diuretics, and an angiotensin-converting-enzyme inhibitor. Expand
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
TLDR
It is concluded that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction. Expand
Association of serum digoxin concentration and outcomes in patients with heart failure.
TLDR
It is demonstrated that higher SDCs were associated with increased mortality and suggested that the effectiveness of digoxin therapy in men with heart failure and a left ventricular ejection fraction of 45% or less may be optimized in the SDC range of 0.5 to 0.8 ng/mL. Expand
β-Adrenergic Receptor Blockade in Chronic Heart Failure
TLDR
This review describes how a treatment that began as a contraindication became an established treatment of chronic heart failure with β-adrenergic blocking agents. Expand
Mechanisms and models in heart failure: the biomechanical model and beyond.
TLDR
Recent advances in the field of heart failure are summarized, with a focus on the new therapeutic strategies that have been developed for treating systolic heart failure. Expand
Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor
TLDR
It is concluded that failing human ventricular myocardium contains a relatively high proportion of beta 2 receptors, due to selective down-regulation of beta 1 receptors, and is available for inotropic stimulation by selective beta 2 agonists. Expand
Myosin heavy chain isoform expression in the failing and nonfailing human heart.
TLDR
The MyHC protein isoform content of human heart samples of known MyHC mRNA composition is determined and it is demonstrated that alphaMyHC protein was easily detectable in 12 nonfailing hearts and translational regulation may be operative. Expand
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