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G proteins: transducers of receptor-generated signals.
- A. Gilman
- Biology, ChemistryAnnual Review of Biochemistry
This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
Complexity and diversity of mammalian adenylyl cyclases.
The discovery of new isoforms of mammalian adenylyl cyclase has revealed unanticipated mechanisms of regulation, including activation or inhibition by the G-protein beta gamma subunit complex, inhibition by G(o) alpha, inhibited by Ca2+, and phosphorylation by protein kinases C and A.
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
- D. Coleman, A. Berghuis, E. Lee, M. Linder, A. Gilman, S. Sprang
- Biology, ChemistryScience
- 2 September 1994
AlF4- complexes formed by the G protein Gi alpha 1 demonstrate specific roles in transition-state stabilization for two highly conserved residues, suggesting a mechanism that may promote release of the beta gamma subunit complex when the alpha subunit is activated by GTP.
Structure of RGS4 Bound to AlF4 −-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.
The GTPase activities of two G protein alpha subunits, Galpha12 and Galpha13, are stimulated by the Rho guanine nucleotide exchange factor p115 RhoGEF, which can directly link heterotrimeric G proteinalpha subunits to regulation of Rho.
Mammalian Ric-8A (Synembryn) Is a Heterotrimeric Gα Protein Guanine Nucleotide Exchange Factor*
Purification and biochemical characterization of recombinant Ric-8A revealed that it is a potent guanine nucleotide exchange factor for a subset of Gα proteins including Gαq, Gαi1, and Gαo, but not Gαs.
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
The crystal structure of a soluble, catalytically active form of adenylyl cyclase in a complex with its stimulatory heterotrimeric G protein alpha subunit (Gsalpha) and forskolin and structural elements important for substrate recognition and catalysis were identified.
p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the α subunits of certain heterotrimeric guanine nucleotide–binding…
A protein binding assay for adenosine 3':5'-cyclic monophosphate.
- A. Gilman
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1970
A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent…