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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system.
- A. R. Schatz, M. Lee, R. Condie, J. Pulaski, N. Kaminski
- BiologyToxicology and applied pharmacology
- 1 February 1997
Results provide further evidence that CB2 is the predominant cannabinoid receptor within the immune system and that this form of the receptor is expressed on T cells.
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.
Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor γ Independently of Cannabinoid Receptors 1 and 2
- C. Rockwell, Natasha T. Snider, Jerry T. Thompson, J. V. Vanden Heuvel, N. Kaminski
- Biology, ChemistryMolecular Pharmacology
- 1 July 2006
PPARγ is identified as a novel intracellular target of 2-AG, which mediates the suppression of IL-2 by 2- AG in a manner that is independent of CB1 and/or CB2.
Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation.
This series of experiments indicates that NF-kappa B/Rel is positively regulated by the cAMP cascade to help initiate iNOS gene expression in response to LPS stimulation of macrophages, which is attenuated by delta 9-THC through the inhibition of cAMP signaling.
In vitro vitellogenin production by carp (Cyprinus carpio) hepatocytes as a screening method for determining (anti)estrogenic activity of xenobiotics.
An in vitro assay was developed for measuring Vtg induction, using cultured primary hepatocytes from genetically uniform strains of carp, and can simultaneously determine aryl hydrocarbon receptor agonist properties, measured as CYP1A induction.
Anandamide-Induced Depressor Effect in Spontaneously Hypertensive Rats: Role of the Vanilloid Receptor
Data indicate that in addition to activation of cannabinoid type 1, anandamide may serve as an endogenous compound to stimulate VR1, leading to a decrease in blood pressure via CGRP release from sensory nerve terminals.
Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes.
- A. Herring, N. Kaminski
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 December 1999
Analysis of up-stream regulation revealed a decrease in phosphorylated CREB/ATF nuclear proteins in PMA/Io-activated thymocytes after CBN treatment, and CBN prevented the phosphorylation-dependent degradation of the nuclear factor-kappaB inhibitory protein IkappaB-alpha.
Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation.
- N. Kaminski, M. Abood, F. Kessler, B. Martin, A. R. Schatz
- Biology, ChemistryMolecular pharmacology
- 1 November 1992
St stereoselective immune modulation was observed with the synthetic bicyclic cannabinoid (-)-CP-55,940 versus (+) CP-56,667 and with 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl and the (-)-enantiomer demonstrated greater immunoinhibitory potency than the (+)-isomer, as measured by the in vitro sheep red blood cell antibody-forming cell response.
Lipopolysaccharide activation of murine splenocytes and splenic B cells increased the expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator.
- R. S. Marcus, M. Holsapple, N. Kaminski
- BiologyThe Journal of pharmacology and experimental…
- 1 December 1998
It is suggested that B-cell activation is sufficient to induce AhR nuclear translocation and binding to dioxin-responsive elements in the promoter region of AhR-responsive genes on LPS activation, and CYP1A1 protein in response to LPS occurred in the absence of exogenous AhR ligand.