FAQ

5-hydroxytryptamine uptake

Known as: 5HT uptake, serotonin import, serotonin uptake 
The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine… (More)

Topic mentions per year

Topic mentions per year

1960-2017
05010019602017

Related topics

Related topics

1 relation
regulation of serotonin uptake

Related mentions per year

Related mentions per year

1960-2018
1960198020002020
5-hydroxytryptamine uptake
regulation of serotonin uptake

Papers overview

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Highly Cited
2000
Highly Cited
2000
Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.
Hypoxia is a well-recognized stimulus for pulmonary blood vessel remodeling and pulmonary hypertension development. One mechanism… (More)
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Highly Cited
2000
Highly Cited
2000
A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.
BACKGROUND Genetic variation of the promoter for the serotonin transporter (5-HTT) gene has been associated with its functional… (More)
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Highly Cited
1999
Highly Cited
1999
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
The human serotonin transporter (5-HTT), encoded by a single gene on chromosome 17q11.2, is expressed in brain and blood cells. 5… (More)
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Highly Cited
1996
Highly Cited
1996
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal… (More)
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Highly Cited
1996
Highly Cited
1996
A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.
The serotonin transporter (5-HTT) is a candidate locus for aetiological involvement in affective disorders. Biochemical studies… (More)
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Highly Cited
1994
Highly Cited
1994
Organization of the human serotonin transporter gene
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed… (More)
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Highly Cited
1992
Highly Cited
1992
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
BACKGROUND Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects… (More)
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1990
1990
5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents.
This study examined the [3H]5-HT-releasing properties of 3,4-methylenedioxymethamphetamine (MDMA) and related agents, all of… (More)
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Highly Cited
1987
Highly Cited
1987
Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor
Paroxetine was shown to be a potent (K i =1.1 nM) and specific inhibitor of [3H]-5-hydroxytryptamine (5-HT) uptake into rat… (More)
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1977
1977
Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor.
1. On the basis of both in vitro and in vivo experiments fluvoxamine has been characterized as a potential anti-depressant drug… (More)
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