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5-hydroxytryptamine uptake

Known as: 5HT uptake, serotonin import, serotonin uptake 
The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine… Expand
National Institutes of Health

Related topics

Related topics

1 relation
regulation of serotonin uptake

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity
BACKGROUND Genetic variation of the promoter for the serotonin transporter (5-HTT) gene has been associated with its functional… Expand
Highly Cited
1999
Highly Cited
1999
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
The human serotonin transporter (5-HTT), encoded by a single gene on chromosome 17q11.2, is expressed in brain and blood cells. 5… Expand
Highly Cited
1999
Highly Cited
1999
Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children
Serotonin content, serotonin uptake sites, and serotonin receptor binding measured in animal studies are all higher in the… Expand
Review
1994
Review
1994
Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs)
  • J. Hyttel
  • International clinical psychopharmacology
  • 1994
    • Corpus ID: 30166780
Established antidepressants including tricyclic antidepressants (TCAs), tetracyclic antidepressants and monoamine oxidase… Expand
Highly Cited
1993
Highly Cited
1993
Primary Structure of the Human Platelet Serotonin Uptake Site: Identity with the Brain Serotonin Transporter
Abstract: A cDNA encoding the human platelet serotonin (5‐HT) uptake site was isolated and sequenced using the PCR. The cDNA… Expand
Highly Cited
1992
Highly Cited
1992
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
BACKGROUND Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects… Expand
Highly Cited
1991
Highly Cited
1991
Cloning of a serotonin transporter affected by antidepressants.
A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The… Expand
Highly Cited
1987
Highly Cited
1987
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin…
This study examines the effects of repeated systemic administration (20 mg/kg s.c., twice daily for 4 days) of 3,4… Expand
Review
1982
Review
1982
Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
  • J. Hyttel
  • Progress in Neuro-Psychopharmacology and…
  • 1982
    • Corpus ID: 36424574
1. Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT… Expand
Highly Cited
1976
Highly Cited
1976
Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.
  • B. K. Koe
  • The Journal of pharmacology and experimental…
  • 1976
    • Corpus ID: 633113
Several compounds of relatively rigid molecular structure have been found to exert strong blockade of monoamine uptake by… Expand
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