K. Lesch

Publications865
h-index122
Citations63,755
Highly Influential Citations2,552
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Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting…
Allelic Variation of Human Serotonin Transporter Gene Expression
TLDR
Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain raphe serotonin (5‐HT) system and allele‐dependent differential 5‐HTT promoter activity may play a role in the expression and modulation of complex traits and behavior.
Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.
TLDR
It is suggested that increased monoamine oxidase A activity is a risk factor for panic disorder in female patients because the longer alleles (3a, 4 and 5) were more active than allele 3.
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
TLDR
A genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls identifies variants surpassing genome- wide significance in 12 independent loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.
Long story short: the serotonin transporter in emotion regulation and social cognition
The gene encoding the serotonin transporter (5-HTT) contains a regulatory variation that has been associated with anxiety-related traits and susceptibility for depression. Here we highlight recent…
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.
TLDR
Data suggest that the presence of a functional 5-HTT is essential for brain 5- HT homeostasis and for 3,4-methylenedioxymethamphetamine-induced hyperactivity.
Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531
TLDR
Simultaneous genotyping of four functional loci of human SLC6A4 , with a reappraisal of 5-HTTLPR and rs25531 shows good agreement with previous work on this topic.
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing ~500K SNP markers identifies novel risk genes and reveals remarkable overlap…
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