Cocaine receptors on dopamine transporters are related to self-administration of cocaine.
It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with theirPotencies in binding to a large number of other presynaptic and postsynaptic binding sites.
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
Characterization of CART neurons in the rat and human hypothalamus
The results indicate that leptin directly acts on CART neurons in distinct nuclei of the rat hypothalamus and the distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans.
Neurotransmitter transporters: recent progress.
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin…
- G. Battaglia, S. Yeh, E. O'hearn, M. Molliver, M. Kuhar, E. D. De Souza
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 September 1987
It is demonstrated that MDMA and MDA cause long-lasting neurotoxic effects with respect to both the functional and structural integrity of serotonergic neurons in brain and measurement of reductions in the density of 5-HT uptake sites provides a means for quantification of the neurodegenerative effects of MDMA andMDA on presynaptic 5- HT terminals.
Cocaine‐ and amphetamine‐regulated transcript peptide immunohistochemical localization in the rat brain
- E. Koylu, P. Couceyro, P. Lambert, M. Kuhar
- BiologyThe Journal of comparative neurology
- 2 February 1998
The localization found here suggests an involvement of CART in many processes, and CART peptides appear to colocalize with some classical neurotransmitters and appear to occur in peripheral neurons as well.
CART peptides: regulators of body weight, reward and other functions
Additional studies aimed at elucidating the physiological effects of the peptides and at characterizing the CART receptor(s) are needed to take advantage of possible therapeutic applications.
Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: A putative mediator of cholecystokinin-induced satiety.
- C. Broberger, K. Holmberg, M. Kuhar, T. Hökfelt
- BiologyProceedings of the National Academy of Sciences…
- 9 November 1999
The present results suggest that CART-derived peptides are present in vagal afferent neurons sensitive to cholecystokinin, suggesting that the role of these peptides in feeding may be explained partly by mediating postprandial satiety effects of chole cysteine.
The dopamine hypothesis of the reinforcing properties of cocaine
Preferential Increases in Nucleus Accumbens Dopamine after Systemic Cocaine Administration Are Caused by Unique Characteristics of Dopamine Neurotransmission
The lower rates for dopamine release and uptake measured in the nucleus accumbens were found to underlie the preferential increase in extracellular dopamine after cocaine, explaining the paradox that cocaine more effectively increases accumbal dopamine despite identical effects on the dopamine transporter in the two regions.