Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity
@article{Hyttel1982CitalopramP, title={Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity}, author={John Hyttel}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={1982}, volume={6}, pages={277-295} }
582 Citations
Comparative pharmacology of selective serotonin re-uptake inhibitors (SSRIs)
- Biology, Chemistry
- 1993
Selective serotonin re-uptake inhibitors (SSRIs) are those which have a high potency ratio of 5-HT-uptakes inhibition as compared to NA-uptaking inhibition, together with slight or no effect on other uptake mechanisms, neurotransmitter receptors, enzymes, etc.
Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor
- Biology, ChemistryPsychopharmacology
- 2004
Paroxetine provides a useful pharmacological tool for investigating 5-HT systems and furthermore should be an antidepressant with reduced tricyclic-like side-effects.
Antagonism by citalopram and tianeptine of presynaptic 5-HT1B heteroreceptors inhibiting acetylcholine release.
- Biology, ChemistryEuropean journal of pharmacology
- 1993
LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug.
- Biology, ChemistryLife sciences
- 1988
Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors.
- Biology, ChemistryAdvances in experimental medicine and biology
- 1995
Some of the background which attracted the attention, and some studies on the chemical series of phenoxyphenylpropylamines and the enantiomers of fluoxetine and its major metabolite norfluoxetines as inhibitors of 5-HT and NE uptake in vitro are presented.
Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia
- Biology, ChemistryJournal of Neural Transmission
- 2005
Alaproclate was found to display a regional selectivity in blocking 5-HT uptake in vivo (measured with the H 75/12-method) and was most potent in the hippocampus and hypothalamus followed by striatum and cerebral cortex with a low potency in the spinal cord.
Serotonin autoreceptor subsensitivity and antidepressant activity.
- Biology, PsychologyEuropean journal of pharmacology
- 1990
Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities
- Psychology, BiologyPsychopharmacology
- 2003
Escitalopram is a very selective 5-HT reuptake inhibitor which is effective in animal models predictive of antidepressant and anxiolytic activities and had very potent anti-aggressive effects when co-administered with l-5-HTP.
Effects of citalopram, a synthetic serotonin uptake inhibitor, on indoleamine and catecholamine concentrations in the cerebrospinal fluid of freely moving rats
- Biology, ChemistryJournal of neural transmission. Parkinson's disease and dementia section
- 1995
CSF results appear to reflect selective inhibition of 5-HT uptake in brain tissues by citalopram that is not associated with changes in catecholamines, indicating that there is coordination of the serotonin and kynurenine pathways in normal rats.
Serotonin uptake inhibitors: uses in clinical therapy and in laboratory research.
- Biology, PsychologyProgress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
- 1995
Serotonin uptake inhibitors have helped in revealing some dynamics of serotonin neurons; for example, when uptake is inhibited and extracellular serotonin concentration increases, presynaptic as well as postsynaptic receptors for serotonin are activated to a greater degree.
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