Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity

@article{Hyttel1982CitalopramP,
  title={Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity},
  author={John Hyttel},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1982},
  volume={6},
  pages={277-295}
}
  • J. Hyttel
  • Published 31 December 1982
  • Chemistry, Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
View on Elsevier
doi.org
585 Citations
Highly Influential Citations
28
Background Citations
166
Methods Citations
30
Results Citations
11

585 Citations

Comparative pharmacology of selective serotonin re-uptake inhibitors (SSRIs)

TLDR
Selective serotonin re-uptake inhibitors (SSRIs) are those which have a high potency ratio of 5-HT-uptakes inhibition as compared to NA-uptaking inhibition, together with slight or no effect on other uptake mechanisms, neurotransmitter receptors, enzymes, etc.

Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor

TLDR
Paroxetine provides a useful pharmacological tool for investigating 5-HT systems and furthermore should be an antidepressant with reduced tricyclic-like side-effects.

Antagonism by citalopram and tianeptine of presynaptic 5-HT1B heteroreceptors inhibiting acetylcholine release.

LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug.

Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors.

TLDR
Some of the background which attracted the attention, and some studies on the chemical series of phenoxyphenylpropylamines and the enantiomers of fluoxetine and its major metabolite norfluoxetines as inhibitors of 5-HT and NE uptake in vitro are presented.

Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia

TLDR
Alaproclate was found to display a regional selectivity in blocking 5-HT uptake in vivo (measured with the H 75/12-method) and was most potent in the hippocampus and hypothalamus followed by striatum and cerebral cortex with a low potency in the spinal cord.

Serotonin uptake inhibitors

TLDR
In contrast to tricyclic antidepressants most of which inhibit receptors for acetylcholine, histamine, NA, 5-HT or DA, most selective 5- HT-uptake inhibitors neither bind to nor inhibit these receptors.

Serotonin autoreceptor subsensitivity and antidepressant activity.

Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities

TLDR
Escitalopram is a very selective 5-HT reuptake inhibitor which is effective in animal models predictive of antidepressant and anxiolytic activities and had very potent anti-aggressive effects when co-administered with l-5-HTP.

Effects of citalopram, a synthetic serotonin uptake inhibitor, on indoleamine and catecholamine concentrations in the cerebrospinal fluid of freely moving rats

  • H. TohgiT. Abe Y. Ikeda
  • Biology, Chemistry
    Journal of neural transmission. Parkinson's disease and dementia section
  • 1995
TLDR
CSF results appear to reflect selective inhibition of 5-HT uptake in brain tissues by citalopram that is not associated with changes in catecholamines, indicating that there is coordination of the serotonin and kynurenine pathways in normal rats.
...

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