H. Horvitz

Publications304
h-index127
Citations81,451
Highly Influential Citations4,252
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
TLDR
Tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O–2 to O2 and H2O2 is reported.
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MicroRNA expression profiles classify human cancers
TLDR
A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
View on Nature
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.
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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
TLDR
Neuronal cytoplasmic protein aggregation and defective RNA metabolism thus appear to be common pathogenic mechanisms involved in ALS and possibly in other neurodegenerative disorders.
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
TLDR
It is shown that let-7 is a heterochronic switch gene that encodes a temporally regulated 21-nucleotide RNA that is complementary to elements in the 3′ untranslated regions of the heteroch chronic genes lin-14, lin-28, Lin-41, lin -42 and daf-12, indicating that expression of these genes may be directly controlled by let- 7.
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Odorant-selective genes and neurons mediate olfaction in C. elegans
View on Elsevier
C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway
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Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
TLDR
It is shown that germ cells, which in hermaphrodites can differentiate into sperm and oocytes, also undergo apoptotic cell death, and it is suggested that apoptosis eliminates excess germ cells that acted as nurse cells to provide cytoplasmic components to maturing oocytes.
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MicroRNA Expression in Zebrafish Embryonic Development
TLDR
Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.
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Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS.
TLDR
The frequency of males among the self progeny of wild-type Caenorhabditis elegans hermaphrodites (5AA; XX) is about one in 500, and fifteen him mutations have been identified that increase this frequency by a factor of ten to 150, as a result of increased X-chromosome nondisjunction.
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