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Presynaptic regulation of the release of catecholamines.
- S. Z. Langer
- BiologyPharmacological reviews
- 1 December 1980
Evidence has accumulated in favour of the view that, in addition to the classical postsynaptic adrenoceptors that mediate the responses of the effector organ, there are also receptors located on the noradrenergic nerve terminals that appear to be involved in the modulation of the release of dopamine and of epinephrine in the central nervous system.
Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects.
- H. Depoortere, B. Zivkovic, G. Bartholini
- Psychology, BiologyThe Journal of pharmacology and experimental…
- 1 May 1986
The highly selective sedative effect of zolpidem (as compared to myorelaxant and anticonvulsant effects) suggests that it may possess a specificity for certain subtypes of benzodiazepine receptors.
Presynaptic regulation of catecholamine release.
- S. Z. Langer
- BiologyBiochemical pharmacology
- 1 July 1974
Unusual Alternative Splicing within the Human Kallikrein Genes KLK2 and KLK3 Gives Rise to Novel Prostate-specific Proteins*
The identification of unusual mRNA splice variants of the human kallikrein genesKLK2 and KLK3 genes that result from inclusion of intronic sequences adjacent to the first exon are reported here.
Preferential metabolism of (—)-3H-norepinephrine through the deaminated glycol in the rat vas deferens
SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977
- S. Z. Langer
- BiologyBritish journal of pharmacology
- 1 August 1977
The topic of the lecture will be the presence of presynaptic receptors in noradrenergic nerve endings and their role in the regulation of the release of the neurotransmitter upon arrival of nerve impulses.
Characterization of [3H]paroxetine binding to rat cortical membranes.
High-affinity [3H]desipramine binding in the peripheral and central nervous system: a specific site associated with the neuronal uptake of noradrenaline.
Metabolism of norepinephrine released by phenoxybenzamine in isolated guinea-pig atria.
- E. Adler-Graschinsky, S. Z. Langer, M. Rubio
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 February 1972
The results support the view that DOPEG is formed predominantly as a result of presynaptic monoamine oxidase activity, and the small increase in spontaneous release of tritiated compounds was accounted for entirely by norepinephrine.
Autoradiographic Localization of [3H]Zolpidem Binding Sites in the Rat CNS: Comparison with the Distribution of [3H]Flunitrazepam Binding Sites
- R. Niddam, A. Dubois, B. Scatton, S. Arbilla, S. Z. Langer
- Biology, ChemistryJournal of neurochemistry
- 1 September 1987
The present data add further support to the view that zolpidem, although structurally unrelated to the benzodiazepines, binds to the Benzodiazepine receptor and possesses selectivity for the BZD1 receptor subtype.