Share This Author
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.
- C. J. Schmidt
- Biology, PsychologyJournal of Pharmacology and Experimental…
The neurochemical effects of the unique psychedelic agent, methylenedioxymethamphetamine (MDMA), indicate it may be a serotonergic neurotoxin related to agents such as p-chloroamphetamine and could be partially blocked by the uptake inhibitor as long as 6 hr after drug administration.
Phosphodiesterases in the CNS: targets for drug development
- F. Menniti, W. S. Faraci, C. J. Schmidt
- Biology, ChemistryNature reviews. Drug discovery
- 1 August 2006
The current state of the art in the burgeoning field of phosphodiesterase pharmacology in the CNS is reviewed, with a focus on the treatment of psychiatric and neurodegenerative disorders.
Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis
Immunohistochemical localization of PDE10A in the rat brain
Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function
In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain.
Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
- S. Sorensen, J. Kehne, C. J. Schmidt
- Psychology, BiologyJournal of Pharmacology and Experimental…
- 1 August 1993
The data indicate that MDL 100,907 has a clozapine-like profile of potential antipsychotic activity with low extrapyramidal sid-effect liability.
5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine.
Glycine transporter type 1 blockade changes NMDA receptor‐mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels
The data suggest that the level of glycine present in the synaptic cleft tightly regulates the NMDAR activity, kept below the ‘set point’ of the N MDAR internalization priming mechanism by the presence of GlyT1‐dependent uptake.
Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo.
- B. M. Baron, M. Dudley, D. McCarty, F. Miller, I. Reynolds, C. J. Schmidt
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 July 1989
Micromolar concentrations of guanine nucleotides and their analogs decreased both agonist and antagonist N-methyl-d-aspartate receptor-effector coupling by competitive antagonism at the glutamate binding site, rather than via interaction with an intracellularly located GTP-binding protein.