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D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
D-Serine appears to be the endogenous ligand for the glycine site of NMDA receptors, suggesting a mechanism by which astrocyte-derived D-serine could modulate neurotransmission. Expand
d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors
Compared the immunohistochemical localizations of d-serine, glycine, and NMDA receptors in rat brain, d-Serine seems to be the endogenous ligand of glycine sites in the telencephalon and developing cerebellum, whereas glycine predominates in the adult cere Bellum, olfactory bulb, and hindbrain. Expand
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin
It is demonstrated that MDMA and MDA cause long-lasting neurotoxic effects with respect to both the functional and structural integrity of serotonergic neurons in brain and measurement of reductions in the density of 5-HT uptake sites provides a means for quantification of the neurodegenerative effects of MDMA andMDA on presynaptic 5- HT terminals. Expand
Semaphorin 3F Is Critical for Development of Limbic System Circuitry and Is Required in Neurons for Selective CNS Axon Guidance Events
Results show that Sema3F is the principal ligand for Npn-2-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry. Expand
Immunohistochemical study of the development of serotonergic neurons in the rat CNS
In this study the development of serotonergic (5-HT) neurons is followed from their initiation of transmitter synthesis until the establishment of an essentially mature morphology. We have used theExpand
The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei
It is concluded that 5‐HT axons in cortex may be subdivided into two distinct projections, in accord with other, recent data showing that the two axon types have different pharmacologic properties and are likely to be functionally different. Expand
Serotonergic Neuronal Systems: What Their Anatomic Organization Tells Us about Function
  • M. Molliver
  • Biology, Medicine
  • Journal of clinical psychopharmacology
  • 1 December 1987
It is proposed that there are two anatomically and functionally distinct serotonergic projections to cortex and that neurons in the dorsal raphe nucleus appear to play a major role in the control of affective state. Expand
Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity
The results establish that MDA and MDMA produce structural damage to 5-HT axon terminals followed by lasting denervation of the forebrain, and the selective degeneration of 5- HT axons indicates that these drugs may serve as experimental tools to analyze the organization and function of5-HT projections. Expand
Neuronal Nitric Oxide Synthase Activation and Peroxynitrite Formation in Ischemic Stroke Linked to Neural Damage
These findings provide a cellular localization for nNOS activation in association with ischemic stroke and establish that NO is not likely a direct neurotoxin, whereas its conversion to peroxynitrite is associated with cell death. Expand
Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus.
It is proposed that the posthypoxic myoclonic jerk of rats is, at least in part, due to disinhibition of the fastigial nucleus produced by patterned Purkinje cell death in the vermis, which is sufficient to induce a form of audiogenic myoclonus, as determined with a neurotoxic dose of ibogaine. Expand