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1,8-dinitropyrene

Known as: DINITROPYRENE, 1,8-, Pyrene, 1,8-dinitro- 
A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

CarcinogensMutagensPyrenes

Papers overview

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Highly Cited
1996
Highly Cited
1996
Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols.
Polycyclic aromatic compounds (PAC) are ubiquitous pollutants in urban air that may pose risks to human health. In order to… 
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Highly Cited
1990
Highly Cited
1990
Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels.
Acetyl-CoA: N-hydroxyarylamine O-acetyltransferase is an enzyme involved in the intracellular metabolic activation of… 
Highly Cited
1987
Highly Cited
1987
SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals.
The umu test system is a newly developed method to evaluate genotoxic activities of a wide variety of environmental carcinogens… 
Highly Cited
1986
Highly Cited
1986
Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.
Restriction enzyme maps were made of the region around exons 1 and 2 of activated c-Ki-ras of a fibrosarcoma (1,8-DNP2) induced… 
1986
1986
Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene.
1,6-Dinitropyrene and 1,8-dinitropyrene are environmental contaminants which are mutagenic in bacteria and cultured mammalian… 
Highly Cited
1985
Highly Cited
1985
Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats.
1-Nitropyrene (1-NP), 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP), which are potent mutagenic components of… 
1984
1984
Metabolism of 1,8-dinitropyrene by Salmonella typhimurium.
Earlier work has shown that many nitroaromatic and nitroheterocyclic compounds are directly 'activated' to their ultimate… 
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Highly Cited
1983
Highly Cited
1983
The basis of the insensitivity of Salmonella typhimurium strain TA98/1,8-DNP6 to the mutagenic action of nitroarenes.
Salmonella typhimurium tester strain TA98/1,8-DNP6 is resistant to the mutagenicity of 1,8-dinitropyrene because it lacks an… 
Highly Cited
1983
Highly Cited
1983
Identification of dinitropyrenes in diesel-exhaust particles. Their probable presence as the major mutagens.
The direct-acting mutagens in diesel particulate extracts were identified. It is concluded that the major mutagens are in all… 
Highly Cited
1982
Highly Cited
1982
The mutagenic potency of 1,8-dinitropyrene in cultured mouse lymphoma cells.
Although non-toxic, 1,8-dinitropyrene (1,8-DNP) was mutagenic for mouse lymphoma L5178Y cell when assayed for induced resistance… 
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