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Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish
TLDR
Avoidance of exposure to HCAs or reduction of HCAs’biological effects as far as possible are to be highly recommended, and usage of microwave ovens for cooking and supplementation of the diet, for example with soy‐isoflavones, which have been found to suppress the occurrence of HCA‐induced breast cancers, should be encouraged. Expand
Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
TLDR
It is suggested that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population. Expand
Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.
TLDR
Comparison of the structures of cDNA clones with that of the genomic clone showed that the 3' heterogeneity is produced by alternative polyadenylation and splicing of mRNA. Expand
Food-derived mutagens and carcinogens.
TLDR
It is suggested that even very low doses of heterocyclic amines form DNA adducts and may be implicated in the development of human cancer under conditions in which many other mutagens-carcinogens, tumor promoters, and factors stimulating cancer progression exist. Expand
Identification of Members of the Protein Phosphatase 1 Gene Family in the Rat and Enhanced Expression of Protein Phosphatase 1α Gene in Rat Hepatocellular Carcinomas
TLDR
Four kinds of cDNA clones of isotypes of catalytic subunits of protein phosphatase 1 (PP‐1) from rat liver and testis cDNA libraries were isolated, and several amino acids located in the middle regions of the peptides were conserved in all the isotypes. Expand
Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.
TLDR
It is concluded that the membrane Atrn has a critical role in normalMyelination in the CNS and would provide insights into the physiology of myelination as well as the etiology of myelin diseases. Expand
cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line.
TLDR
The aberrant tyrosine kinase activity induced by the rearrangement of ret proto-oncogene could be involved in the development of papillary thyroid carcinoma. Expand
Exposure to heterocyclic amines.
TLDR
It is strongly suggested that humans are continuously exposed to HAs derived from food in the normal diet, which are in the same range as those of other carcinogens such as N-nitrosodimethylamine and benzo[a]pyrene to which humans are exposed. Expand
Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors.
TLDR
Comparison MS-RDA of one hepatocellular carcinoma and of background liver tissue of one mouse treated with a food carcinogen and a methylation-sensitive-representational difference analysis method, which is a promising approach to identify DNA fragments differentially methylated in two DNA sources. Expand
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