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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
Runx3/Pebp2alphaC null mouse gastric mucosa exhibits hyperplasias due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-inhibitory andExpand
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.
The nucleotide sequence of the Japanese type of hepatitis C virus (HCV-J) genome, consisting of 9413 nucleotides, was determined by analyses of cDNA clones from plasma specimens from JapaneseExpand
Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish
Avoidance of exposure to HCAs or reduction of HCAs’biological effects as far as possible are to be highly recommended, and usage of microwave ovens for cooking and supplementation of the diet, for example with soy‐isoflavones, which have been found to suppress the occurrence of HCA‐induced breast cancers, should be encouraged. Expand
A simple and rapid method for generating a deletion by PCR.
A simple and rapid mutational method by using polymerase chain reaction (PCR) in which oligonucleotide primers are designed in inverted tail-to-tail directions to amplify the cloning vector together with the target sequence, which shows excellent efficiency of 100% with only one mjsincorporation. Expand
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Results indicate that PGE(2) contributes to colon carcinogenesis through its actions mediated through EP(1) and EP(4) receptors; therefore, antagonists for these two receptors may be good candidates as chemopreventive agents against colon cancer. Expand
Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.
The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined and a protease gene that is responsible for processing the gag precursor protein was found. Expand
Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.
Comparison of the structures of cDNA clones with that of the genomic clone showed that the 3' heterogeneity is produced by alternative polyadenylation and splicing of mRNA. Expand
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), at a dose of 400 ppm in the diet for 52 weeks were histopathologicallyExpand
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
The results strongly suggest that prostaglandin E2 contributes to colon carcinogenesis to some extent through its action at the EP1 receptor, and EP1 antagonists may be good candidates as chemopreventive agents for colon cancer. Expand
Quantification of genistein and genistin in soybeans and soybean products.
Daily intake of genistein and genistin by the Japanese is calculated to be 1.5-4.3 mg/person, much higher than those for Americans or Western Europeans, whose mortality rates for breast, colon and prostate cancers are greater than the Japanese. Expand