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Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM10 Air Particulate Material Using in Vitro Gene Expression Assays
Polar and nonpolar fractions prepared from an organic extract of inhalable air particulate material collected from an urban location in downtown Toronto, Ontario, Canada, were examined for estrogenExpand
Type I nitroreductases of Escherichia coli.
Analysis of partially purified crude extract of Escherichia coli K12 by chromatography and gel electrophoresis has resulted in the separation of three distinct activities which catalyse the reductionExpand
Carcinogenicity of Monochloro-1,2-Propanediol (α-Chlorohydrin, 3-MCPD)
The tumors reported in F344 rats are concluded to have developed as a result of nongenotoxic mechanisms and are considered not to be relevant to humans exposed to trace amounts of 3-MCPD. Expand
Toxicological significance of DNA adducts: summary of discussions with an expert panel.
The current technological capabilities for detection of DNA adducts exceed the ability to define the biological significance of adductS as it relates to toxicity or health outcome, and an Expert Panel concluded that human DNAAdduct data have utility in several aspects of risk assessment. Expand
Chemico/biological investigation of contaminated sediment from the hamilton harbour area of Western Lake Ontario
Highly contaminated sediment from the Hamilton Harbour area of western Lake Ontario was examined using a bioassay‐directed fractionation methodology and the majority of the mutagenic activity displayed by the sample extract was found in the fraction containing the polycyclic aromatic hydrocarbons. Expand
Analysis of high-molecular-mass polycyclic aromatic hydrocarbons in environmental samples using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
Results indicated that some high-molecular-mass PAHs may be characteristic of contamination by coal tar. Expand
Chemical and biological profiles of sediments as indicators of sources of genotoxic contamination in Hamilton Harbour. Part I: analysis of polycyclic aromatic hydrocarbons and thia-arene compounds.
Results indicated that areas of coal tar-contaminated sediment are potential contributors to the overall contaminant burden of sediments and suspended sediments in Hamilton Harbour and indicated that contaminants related to mobile combustion sources were entering the harbour via a major tributary. Expand
Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems.
Both VP16 and VM26 which interact with mammalian DNA topoisomerase II, are strongly mutagenic in Chinese hamster ovary cells as indicated by the induction of mutations at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci, and production of DNA strand breaks and sister-chromatid exchanges. Expand
Action of nitrofurans on E. coli: mutation and induction and repair of daughter-strand gaps in DNA.
The antibacterial and mutagenic potency of 9 nitrofurans in "treat and plate" experiments varied over almost 5 orders of magnitude, with the wvrA strain was 6--7-fold more mutable with both these agents than was WP2. Expand
Preliminary comparisons between mutagenicity and magnetic susceptibility of respirable airborne particulate
The magnetic susceptibility of respirable urban airborne particulate and the mutagenic potency and organic content of extracts prepared from these particles are both related to mobile and stationaryExpand