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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Role of plant polyphenols in genomic stability.
- L. Ferguson
- BiologyMutation research
- 18 April 2001
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Role of gut microbiota in
The complex microbial ecosystem of the mammalian gut, the underlying genetic factors that predispose to Crohn’s disease, and how these gene variants may alter host–microbe interactions and propagate inflammation are discussed.
Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice
An up-to-date overview of the various aspects of nutrigenetics and Nutrigenomics relevant to health practitioners who are seeking a better understanding of this new frontier in nutrition research and its potential application to dietetic practice is presented.
Personalised nutrition and health
Jose Ordovas and colleagues consider that nutrition interventions tailored to individual characteristics and behaviours have promise but more work is needed before they can deliver
Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn's disease patients
A Mediterranean-inspired anti-inflammatory diet was developed and used in a 6-week intervention in a Crohn's disease population and significant changes in gene expression were observed, highlighting the increased sensitivity of using transcriptomics when compared to the established biomarkers.
HUman MicroNucleus project: international database comparison for results with the cytokinesis‐block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and…
The best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods.
Why interleukin-10 supplementation does not work in Crohn's disease patients.
- G. Marlow, Dominique van Gent, L. Ferguson
- Medicine, BiologyWorld journal of gastroenterology
- 7 July 2013
It is concluded that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL- 10 supplementation could be of benefit.