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Type I nitroreductases of Escherichia coli.
Analysis of partially purified crude extract of Escherichia coli K12 by chromatography and gel electrophoresis has resulted in the separation of three distinct activities which catalyse the reductionExpand
Mode of action of nitrofurazone.
Partially purified nitrofurazone reductase preparations catalyze the conversion of nitro furazone to compounds which bind to protein and are not removed by prolonged dialysis against 8 m urea or by cold acid. Expand
On the mutagenicity of nitrofurans.
Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking theExpand
Mutagenicity of nitrofuran derivatives: review.
Genetics of nitrofurazone resistance in Escherichia coli.
A variety of crosses established that the genes that control reductase activity "nitrofuran sensitivity genes" (nfsA and nfsB) are both located close to gal, that the most probable sequence is lac nFSB gal nfsA, and that the single-step mutants with an intermediate level of resistance are nFSA nfs B(+). Expand
Chemical Nature of an Insect Gall Growth-Factor.
Effect of activated nitrofurans on DNA.
Experiments with three other nitrofurans show that there are considerable differences in the degree to which DNA is damaged by activated metabolites of various derivatives and that the potency of the compounds as mutagens and carcinogens is correlated with the amount of damage caused to minicell DNA. Expand
Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems.
Both VP16 and VM26 which interact with mammalian DNA topoisomerase II, are strongly mutagenic in Chinese hamster ovary cells as indicated by the induction of mutations at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci, and production of DNA strand breaks and sister-chromatid exchanges. Expand
Action of nitrofurans on E. coli: mutation and induction and repair of daughter-strand gaps in DNA.
The antibacterial and mutagenic potency of 9 nitrofurans in "treat and plate" experiments varied over almost 5 orders of magnitude, with the wvrA strain was 6--7-fold more mutable with both these agents than was WP2. Expand
Cytotoxicity and DNA damage to mammalian cells by nitrofurans.
It is suggested that toxicity and DNA damage may result from the actions of toxic intermediates in the metabolic reduction of nitrofurans. Expand