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Type I nitroreductases of Escherichia coli.
Analysis of partially purified crude extract of Escherichia coli K12 by chromatography and gel electrophoresis has resulted in the separation of three distinct activities which catalyse the reduction…
On the mutagenicity of nitrofurans.
Genetics of Nitrofurazone Resistance in Escherichia coli
A variety of crosses established that the genes that control reductase activity "nitrofuran sensitivity genes" (nfsA and nfsB) are both located close to gal, that the most probable sequence is lac nFSB gal nfsA, and that the single-step mutants with an intermediate level of resistance are nFSA nfs B(+).
Mode of Action of Nitrofurazone
Partially purified nitrofurazone reductase preparations catalyze the conversion of nitro furazone to compounds which bind to protein and are not removed by prolonged dialysis against 8 m urea or by cold acid.
Mutagenicity of nitrofuran derivatives: review.
- D. R. McCalla
- ArtEnvironmental mutagenesis
Effect of activated nitrofurans on DNA.
Action of nitrofurans on E. coli: mutation and induction and repair of daughter-strand gaps in DNA.
Chemical Nature of an Insect Gall Growth-Factor.
The fact that injections of whole insect extracts do not, in general, produce typical galls should not be considered surprising since gall formation probably depends upon the precise placing of the right amount of the appropriate chenmicals in a way that is difficult if not impossible to duplicate experimentally.
Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems.
Both VP16 and VM26 which interact with mammalian DNA topoisomerase II, are strongly mutagenic in Chinese hamster ovary cells as indicated by the induction of mutations at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci, and production of DNA strand breaks and sister-chromatid exchanges.
NITROFURAN DERIVATIVES AS RADIOMIMETIC AGENTS: CROSS-RESISTANCE STUDIES WITH ESCHERICHIA COLI.
- D. R. McCalla
- Chemistry, BiologyCanadian journal of microbiology
- 1 April 1965
It is concluded that radiomimetic nitrofurans probably exert their effect on E. coli through damage to DNA.