Skip to search formSkip to main contentSkip to account menu

valdecoxib

Known as: 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide, 4-(5-methyl-3-phenyl-isoxazol-4-yl)benzenesulfonamide, valdecoxib [Chemical/Ingredient] 
A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (1)

Bextra

Broader (3)

Cyclooxygenase 2 InhibitorsIsoxazolesSulfonamides
Degenerative polyarthritisDrug AllergyDysmenorrheaPregnancy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Highly Cited
2007
Highly Cited
2007
The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib.
A large number of functionally substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the… 
Review
2006
Review
2006
Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials.
CONTEXT Adverse effects of selective cyclooxygenase 2 (COX-2) inhibitors on renal events and arrhythmia have been controversial… 
Highly Cited
2005
Highly Cited
2005
Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury.
Highly Cited
2005
Highly Cited
2005
Parecoxib, valdecoxib, and cardiovascular risk.
Selective inhibitors of cyclooxygenase (COX)-21 depress prostacyclin (PGI2) but not COX-1–derived thromboxane A2. The effects of… 
Highly Cited
2004
Highly Cited
2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
By optimizing binding to a selected target protein, modern drug research strives to develop safe and efficacious agents for the… 
Highly Cited
2004
Highly Cited
2004
Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs.
Highly Cited
2003
Highly Cited
2003
Differential inhibition of fracture healing by non‐selective and cyclooxygenase‐2 selective non‐steroidal anti‐inflammatory drugs
Review
2003
Review
2003
Cyclooxygenase-2 Inhibitors in Postoperative Pain Management: Current Evidence and Future Directions
NONSTEROIDAL antiinflammatory drugs (NSAIDs) have been shown to reduce pain and opioid consumption and often accelerate recovery… 
Highly Cited
2000
Highly Cited
2000
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)