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Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
TLDR
Increasing age, current cigarette smoking, previous cataract surgery, and a family history of AMD showed strong and consistent associations with late AMD.
Minimal Clinically Important Difference in the Fibromyalgia Impact Questionnaire
TLDR
Analysis of analyses of the Fibromyalgia Impact Questionnaire indicates that a 14% change in the FIQ total score is clinically relevant, and results of these analyses should enhance the clinical utility of the FIZ in research and practice.
Burden and health care resource utilization in neovascular age-related macular degeneration: findings of a multicountry study.
TLDR
The evidence of extensive decline in quality of life and increased need of daily living assistance for patients with NV-AMD compared with a control population substantiates the need for new treatments that prevent vision loss and progression to blindness.
The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States
TLDR
FM imposes a substantial humanistic burden on patients in the United States, and leads to substantial productivity loss, despite treatment, and this burden is higher among subjects with worse FM severity.
The comparative economic burden of mild, moderate, and severe fibromyalgia: results from a retrospective chart review and cross-sectional survey of working-age U.S. adults.
TLDR
This study examined the direct and indirect costs of fibromyalgia by severity level in routine clinical practice in the United States using a patient-centric approach and found differences across severity levels significantly differed.
Burden of illness of neovascular age-related macular degeneration in Canada.
TLDR
The findings emphasize the need for new treatments for neovascular AMD that will prevent vision loss and progression to blindness in order to lessen the ensuing economic burden.
Impact of fibromyalgia severity on health economic costs
TLDR
FM subjects were found to have substantial costs, over 75% of which were driven by indirect costs from lost productivity, which increased as FM severity increased, resulting in a more than 200% difference in cost between mild and severe FM.
Delay in treating age-related macular degeneration in Spain is associated with progressive vision loss
TLDR
Delayed treatment of patients newly diagnosed with NV-AMD is associated with substantial visual acuity loss and patients with more severe vision loss prior to treatment tended to report more depression.
Evaluation of the safety and efficacy of pregabalin in older patients with neuropathic pain: results from a pooled analysis of 11 clinical studies
TLDR
Pregabalin (150-600 mg/day) significantly reduced pain in older patients (age ≥65 years) with neuropathic pain and improvements in pain were comparable to those observed in younger patients, making pregabalin an important treatment option for older patients with pain of neuropathic origin.
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