M. Giorgi

Publications297
h-index23
Citations2,157
Highly Influential Citations83
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Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax).
TLDR
The in vivo and in vitro effects of enrofloxacin on hepatic p450 enzymes of sea bass, a widespread food-producing fish, have been evaluated and it is found that the EF seems to be a powerful inhibitor of p450s in the sea bass.
Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration
Abstract Tramadol (T) is a centrally acting analgesic structurally related to codeine and morphine. This drug displays a weak affinity for the μ and δ-opioid receptors, and weaker affinity for the…
Effects of β-naphthoflavone on the cytochrome P450 system, and phase II enzymes in gilthead seabream (Sparus aurata)
TLDR
Dose–response experiments demonstrated that EROD was significantly enhanced in liver by a single injection of 0.3 mg/kg β-NF and was the most sensitive measurement for CYP 1A-like induction, but not MEROD and PROD activities in heart and kidney.
Pharmacokinetics of the novel atypical opioid tapentadol following oral and intravenous administration in dogs.
TLDR
It is shown that TAP may be useful as an analgesic in the dog, but further studies, including in dogs requiring analgesia, are required to confirm efficacy.
Toxicokinetics and tissue distribution of nivalenol in broiler chickens.
TLDR
The results suggest that NIV is absorbed from the gastrointestinal tract with low bioavailability and it has the ability to diffuse into various tissues of broilers.
Effect of chronic and acute heat challenges on fecal microbiota composition, production, and thermoregulation traits in growing pigs1,2
TLDR
Investigating the impact of heat challenges on gut microbiota composition in growing pigs and its relationship with pigs’ performance and thermoregulation responses revealed that the Turicibacter–Sarcina–Clostridium sensu stricto dominated enterotype was better adapted to heat stress conditions with lower thermoreGulation variations.
Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study.
TLDR
The study showed that MRT has a different pharmacokinetic profile in the dog compared to other species, while 8-OH attained the highest concentrations.
Pharmacokinetic and urine profile of tramadol and its major metabolites following oral immediate release capsules administration in dogs
TLDR
After oral administration of tramadol immediate release capsules, the absorption of the active ingredient was rapid, but its rapid metabolism quickly transformed the parental drug to high levels of M5 and M2, showing an extensive elimination via the kidney.
Quantification of tapentadol in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
TLDR
This was a simple and effective method using HPLC-FL to detect TAP in plasma, which may be useful for future pharmacokinetic studies.
Tramadol Vs Tapentadol: Anew Horizon in Pain Treatment?
TLDR
Tapentadol is a novel, atypical opioid with a unique mechanism of action that has great potential for veterinary use because it exists as a single enantiomer only, it does not require metabolic activation to be effective and adverse effects triggered by the serotonin reuptake inhibition action are negligible.
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