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Cyclooxygenase 2 Inhibitors

Known as: Cyclooxygenase-2 Inhibitors, Inhibitors, COX2, COX2 Inhibitors 
A nonsteroidal anti-inflammatory drug used to relieve pain and inflammation. COX-2 inhibitors are being studied in the prevention of colon polyps… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
BACKGROUND Low-dose aspirin has proven effectiveness in secondary and primary prevention of cardiovascular events, but is also… Expand
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Highly Cited
2016
Highly Cited
2016
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with… Expand
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Highly Cited
2005
Highly Cited
2005
The authors analyzed data from 52 randomized placebo-controlled trials (4,893 adults) testing acetaminophen, nonsteroidal… Expand
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Review
2001
Review
2001
Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that… Expand
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Highly Cited
2000
Highly Cited
2000
We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood… Expand
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Highly Cited
2000
Highly Cited
2000
This study investigates the apoptotic activity of the cyclooxygenase-2 (COX-2) inhibitor celecoxib in prostate carcinoma cells… Expand
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Review
1998
Review
1998
Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from… Expand
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Highly Cited
1998
Highly Cited
1998
Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs reduce the risk of colon cancer and that… Expand
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Highly Cited
1996
Highly Cited
1996
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2… Expand
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Highly Cited
1994
Highly Cited
1994
We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the… Expand
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