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Cyclooxygenase 2 Inhibitors

Known as: Cyclooxygenase-2 Inhibitors, Inhibitors, COX2, COX2 Inhibitors 
A nonsteroidal anti-inflammatory drug used to relieve pain and inflammation. COX-2 inhibitors are being studied in the prevention of colon polyps… 
National Institutes of Health

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Etodolaccelecoxibetoricoxiblumiracoxib
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Review
2007
Review
2007
Anti-inflammatory drugs in the 21st century.
Historically, anti-inflammatory drugs had their origins in the serendipitous discovery of certain plants and their extracts being… 
Highly Cited
2004
Highly Cited
2004
Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial
Review
2002
Review
2002
Cyclooxygenase-2: a therapeutic target.
Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of… 
Highly Cited
2002
Highly Cited
2002
A rat model of bone cancer pain
Highly Cited
2001
Highly Cited
2001
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
BACKGROUND Patients with arthritis and vascular disease may receive both low-dose aspirin and other nonsteroidal antiinflammatory… 
Highly Cited
2000
Highly Cited
2000
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.
Recent studies from our laboratory have shown that derivatization of the carboxylate moiety in substrate analogue inhibitors… 
Highly Cited
2000
Highly Cited
2000
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.
All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) isozymes to different extents, which accounts… 
Review
2000
Review
2000
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors.
In summary, COX-2 is a highly regulated gene product that catalyzes the local production of PGs in pathologic and physiologic… 
Highly Cited
1999
Highly Cited
1999
Chemopreventive activity of celecoxib, a specific cyclooxygenase‐2 inhibitor, and indomethacin against ultraviolet light–induced skin carcinogenesis
Epidemiological and dietary studies suggest that nonsteroidal anti‐inflammatory drugs (NSAIDs) reduce the risk of colon cancer… 
Highly Cited
1999
Highly Cited
1999
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition.
UV light is a complete carcinogen, inducing both basal and squamous cell skin cancers. The work described uses the selective COX… 
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