Cyclooxygenase 2 Inhibitors
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Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with… Expand Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual pain, and headache. Although they are… Expand Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that… Expand BACKGROUND
Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the… Expand We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood… Expand Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from… Expand To explore the role of cyclooxygenase (COX) in endothelial cell migration and angiogenesis, we have used two in vitro model… Expand Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs reduce the risk of colon cancer and that… Expand A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block… Expand Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2… Expand