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celecoxib

Known as: 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, Celecoxib [Chemical/Ingredient], Célécoxib 
A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the number of colorectal adenomas in animals… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer… Expand
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support many human cancers. Inhibition of COX-2 by… Expand
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Highly Cited
2000
Highly Cited
2000
CONTEXT Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably… Expand
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Highly Cited
2000
Highly Cited
2000
This study investigates the apoptotic activity of the cyclooxygenase-2 (COX-2) inhibitor celecoxib in prostate carcinoma cells… Expand
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Highly Cited
2000
Highly Cited
2000
Epidemiological observations and laboratory research have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the… Expand
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Highly Cited
2000
Highly Cited
2000
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been observed to reduce the relative risk of breast cancer. This prompted our… Expand
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Highly Cited
1999
Highly Cited
1999
CONTEXT In vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not COX-1, suggesting that this drug may… Expand
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Highly Cited
1998
Highly Cited
1998
Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs reduce the risk of colon cancer and that… Expand
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Highly Cited
1997
Highly Cited
1997
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block… Expand
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