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celecoxib

Known as: 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, Celecoxib [Chemical/Ingredient], Célécoxib 
A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity… 
National Institutes of Health

Related topics

Related topics

35 relations
Adenomatous Polyposis ColiAngiogenesis InhibitionCYP2C9 protein, humanCelecoxib:MCnc:Pt:Ser/Plas:Qn

Broader (2)

Anti-Inflammatory Agents, Non-SteroidalCyclooxygenase 2 Inhibitors

Narrower (3)

CelebrexSC 58635celecoxib-NBD

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects.
Highly Cited
2007
Highly Cited
2007
Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations.
Biopharmaceutical evaluation of crystalline celecoxib salts in novel solid formulations, which were designed to simultaneously… 
Highly Cited
2006
Highly Cited
2006
Indomethacin and Celecoxib Impair Rotator Cuff Tendon-to-Bone Healing
Background Nonsteroidal anti-inflammatory drugs are commonly prescribed after rotator cuff repair. These agents can impair bone… 
Review
2005
Review
2005
Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
Highly Cited
2004
Highly Cited
2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
By optimizing binding to a selected target protein, modern drug research strives to develop safe and efficacious agents for the… 
Highly Cited
2004
Highly Cited
2004
Celecoxib Induces Functional Recovery after Intracerebral Hemorrhage with Reduction of Brain Edema and Perihematomal Cell Death
The selective cyclooxygenase-2 (COX-2) inhibitor has been reported to have antiinflammatory, neuroprotective, and antioxidant… 
Highly Cited
2004
Highly Cited
2004
Stability and Solubility of Celecoxib-PVP Amorphous Dispersions: A Molecular Perspective
AbstractPurpose. The purpose of the current study is to evaluate the solubility advantage offered by celecoxib (CEL) amorphous… 
Highly Cited
2004
Highly Cited
2004
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.
Highly Cited
2000
Highly Cited
2000
Postoperative analgesic effects of celecoxib or rofecoxib after spinal fusion surgery.
UNLABELLED Nonsteroidal antiinflammatory drugs are recommended for the multimodal management of postoperative pain and may have a… 
Highly Cited
1999
Highly Cited
1999
Chemopreventive activity of celecoxib, a specific cyclooxygenase‐2 inhibitor, and indomethacin against ultraviolet light–induced skin carcinogenesis
Epidemiological and dietary studies suggest that nonsteroidal anti‐inflammatory drugs (NSAIDs) reduce the risk of colon cancer… 
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