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Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model.
Curcumin a poly-phenolic compound possesses diverse pharmacologic activities; however, its development as a drug has been severely impeded by extremely poor oral bioavailability. Poor aqueousExpand
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Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids.
The existence of different solid-state forms such as polymorphs, solvates, hydrates, and amorphous form in pharmaceutical drug substances and excipients, along with their downstream consequences inExpand
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Compression physics in the formulation development of tablets.
The advantages of high-precision dosing, manufacturing efficiency, and patient compliance make tablets the most popular dosage forms. Compaction, an essential manufacturing step in the manufacture ofExpand
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Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum
HIV-associated dementia complex is a serious disabling disease characterized by cognitive, behavioral and motor dysfunction. Basal ganglia involvement in HIV-1 infection may be responsible for someExpand
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Polymorphs, Salts, and Cocrystals: What’s in a Name?
The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredientsExpand
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Characterization of solid-state forms of celecoxib.
This study deals with the generation and characterization of various solid-state forms of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor. The drug was subjected to polymorphic screen usingExpand
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Role of molecular interaction in stability of celecoxib-PVP amorphous systems.
Stabilization of an amorphous solid against devitrification can be achieved using additives that interact specifically with the parent molecule, and restrain it from rearranging into a crystalExpand
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Solid State Characterization of Commercial Crystalline and Amorphous Atorvastatin Calcium Samples
Atorvastatin calcium (ATC), an anti-lipid BCS class II drug, is marketed in crystalline and amorphous solid forms. The objective of this study was to perform solid state characterization ofExpand
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Oxidative damage induced by the injection of HIV-1 Tat protein in the rat striatum
Oxidative stress has been hypothesized to play a role in the pathogenesis of different neurodegenerative disorders, including HIV-related dementia. Tat, a nonstructural protein of HIV, is implicatedExpand
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Quantification of olanzapine polymorphs using powder X-ray diffraction technique.
Accurate quantification of crystalline phases present in drug materials is becoming increasingly important, due to stringent regulatory concerns about polymorph characterization and control in drugExpand
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