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Ibuprofen: pharmacology, efficacy and safety
ObjectivesThis review attempts to bring together information from a large number of recent studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is widely usedExpand
Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases
AbstractObjectivesThis review examines the pharmacokinetics, modes of action and therapeutic properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in the treatment ofExpand
Anti-inflammatory drugs in the 21st century.
Historically, anti-inflammatory drugs had their origins in the serendipitous discovery of certain plants and their extracts being applied for the relief of pain, fever and inflammation. WhenExpand
Antioxidant defense and trace element imbalance in patients with postradiation syndrome
More than 6000 residents of Latvia were involved in recovery work in Chernobyl. They were healthy men exposed to substantial ionizing radiation (0.01–0.5 Gy). Now, these recovery workers suffer fromExpand
Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro
Cannabinoids have analgesic, immunomodulatory and anti‐inflammatory properties and attenuate joint damage in animal models of arthritis. In this study the mechanisms of action of the syntheticExpand
Osteoarthritis of the knee and hip. Part I: aetiology and pathogenesis as a basis for pharmacotherapy
Objectives  Osteoarthritis (OA) of the knee and hip is among the most frequent and debilitating arthritic conditions. Aside from surgical intervention in severe cases, conventional treatment involvesExpand
Poly L-histidine. A potent stimulator of superoxide generation in human blood leukocytes.
Poly-L-histidine (PHSTD) of molecular weight 26,000 induced the generation of large amounts of superoxide (O2-) and hydrogen peroxide (H2O2) in human neutrophils (PMNs). Despite its low solubility atExpand
Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide
Abstract.This review summarizes the principal therapeutic responses to the preferential COX-2 NSAID, nimesulide, in treating musculo-skeletal joint symptoms and various acute and chronic painExpand
The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice
ConclusionsThe findings presented in this report show that: (1) 5-lipoxygenase inhibitors and some leukotriene antagonists protect the gastric mucosa against lesions induced by oral or parenteralExpand
Non-Steroidal Anti-Inflammatory Drug-Induced Gastropathy