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Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstemExpand
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Lipid peroxidation-DNA damage by malondialdehyde.
  • L. Marnett
  • Chemistry, Medicine
  • Mutation research
  • 8 March 1999
Malondialdehyde is a naturally occurring product of lipid peroxidation and prostaglandin biosynthesis that is mutagenic and carcinogenic. It reacts with DNA to form adducts to deoxyguanosine andExpand
  • 1,060
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Oxyradicals and DNA damage.
  • L. Marnett
  • Medicine, Chemistry
  • Carcinogenesis
  • 1 March 2000
A major development of carcinogenesis research in the past 20 years has been the discovery of significant levels of DNA damage arising from endogenous cellular sources. Dramatic improvements inExpand
  • 1,671
  • 36
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics of curcumin inExpand
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Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides*
Cyclooxygenase-2 (COX-2) action on the endocannabinoids, 2-arachidonylglycerol (2-AG) and anandamide (AEA), generates prostaglandin glycerol esters (PG-G) and ethanolamides (PG-EA), respectively. TheExpand
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Aspirin and the potential role of prostaglandins in colon cancer.
The arachidonic acid cascade generates a family of bioactive lipids that modulate diverse physiological and pathophysiological responses. Although there has been a great deal of interest in theExpand
  • 747
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Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.
A constellation of reactive intermediates — electrophiles and free radicals — capable of damaging cellular constituents is generated during normal physiological or pathophysiological processes. TheExpand
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Prostaglandin and thromboxane biosynthesis.
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2 alpha, 9 alpha, 11 beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. WeExpand
  • 446
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Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2*
Cyclooxygenases (COX) play an important role in lipid signaling by oxygenating arachidonic acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases exist which differ inExpand
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Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
This publication is the seventh in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers' Association (FEMA). In 1993, the Panel initiated aExpand
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