Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
- M. D. Van Sickle, M. Duncan, +12 authors K. Sharkey
- Biology, Medicine
- Science
- 14 October 2005
The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem… Expand
Lipid peroxidation-DNA damage by malondialdehyde.
- L. Marnett
- Chemistry, Medicine
- Mutation research
- 8 March 1999
Malondialdehyde is a naturally occurring product of lipid peroxidation and prostaglandin biosynthesis that is mutagenic and carcinogenic. It reacts with DNA to form adducts to deoxyguanosine and… Expand
Oxyradicals and DNA damage.
- L. Marnett
- Medicine, Chemistry
- Carcinogenesis
- 1 March 2000
A major development of carcinogenesis research in the past 20 years has been the discovery of significant levels of DNA damage arising from endogenous cellular sources. Dramatic improvements in… Expand
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
- R. Sharma, H. McLelland, +7 authors W. Steward
- Medicine
- Clinical cancer research : an official journal of…
- 1 July 2001
Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics of curcumin in… Expand
Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides*
- K. Kozak, B. Crews, +5 authors L. Marnett
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 22 November 2002
Cyclooxygenase-2 (COX-2) action on the endocannabinoids, 2-arachidonylglycerol (2-AG) and anandamide (AEA), generates prostaglandin glycerol esters (PG-G) and ethanolamides (PG-EA), respectively. The… Expand
Aspirin and the potential role of prostaglandins in colon cancer.
- L. Marnett
- Medicine
- Cancer research
- 15 October 1992
The arachidonic acid cascade generates a family of bioactive lipids that modulate diverse physiological and pathophysiological responses. Although there has been a great deal of interest in the… Expand
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.
- L. Marnett, J. Riggins, J. West
- Chemistry, Medicine
- The Journal of clinical investigation
- 1 March 2003
A constellation of reactive intermediates — electrophiles and free radicals — capable of damaging cellular constituents is generated during normal physiological or pathophysiological processes. The… Expand
Prostaglandin and thromboxane biosynthesis.
- W. Smith, L. Marnett, D. Dewitt
- Chemistry, Medicine
- Pharmacology & therapeutics
- 1991
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2 alpha, 9 alpha, 11 beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We… Expand
Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2*
- K. Kozak, S. Rowlinson, L. Marnett
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 27 October 2000
Cyclooxygenases (COX) play an important role in lipid signaling by oxygenating arachidonic acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases exist which differ in… Expand
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
- R. Smith, T. Adams, +9 authors I. Sipes
- Chemistry, Medicine
- Food and chemical toxicology : an international…
- 1 July 2002
This publication is the seventh in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers' Association (FEMA). In 1993, the Panel initiated a… Expand