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Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.
Lipid peroxidation-DNA damage by malondialdehyde.
  • L. Marnett
  • Chemistry, Medicine
    Mutation research
  • 8 March 1999
M1G appears to be a major endogenous DNA adduct in human beings that may contribute significantly to cancer linked to lifestyle and dietary factors and high throughput methods for its detection and quantitation will be extremely useful for screening large populations.
Oxyradicals and DNA damage.
  • L. Marnett
  • Medicine, Chemistry
  • 1 March 2000
The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
The results suggest that Curcuma extract can be administered safely to patients at doses of up to 2.2 g daily, equivalent to 180 mg of curcumin, and that larger clinical trials ofcurcumin has low oral bioavailability in humans and may undergo intestinal metabolism.
Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides*
The results define the in vitrodiversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo.
Aspirin and the potential role of prostaglandins in colon cancer.
This Perspective was written to highlight some of the existing literature on the aspirin-inhibitable branch of the arachidonic acid cascade and cancer, to apply that liter ature to colon cancer where possible, and to identify deficien cies in knowledge that need to be addressed.
Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2*
Results identify a distinct function for COX-2 in endocannabinoid metabolism and in the generation of a new family of prostaglandins derived from diacylglycerol and 2-AG.
Prostaglandin and thromboxane biosynthesis.
The three major steps in prostanoid formation are discussed and the roles of aspirin and other nonsteroidal anti-inflammatory drugs, dexamethasone and other anti- inflammatory steroids, platelet-derived growth factor (PDGF), and interleukin-1 in prostaglandin metabolism are discussed.
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.
An overview of DNA and protein damage by endogenous electrophiles and oxidants is provided and an introduction to the consequences of this damage.
Prostaglandin endoperoxide synthase: structure and catalysis.
The properties of PGH synthase are described, the enzyme which catalyzes the committed step in the synthesis of prostaglandins and thromboxane is described, and a model for the active site is proposed.