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Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases.
Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) and selective… Expand
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting… Expand
The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling. The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue… Expand
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.
Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of the most common diseases among mammals. Although this musculoskeletal disorder has been described in… Expand
Inflammation in osteoarthritis.
- S. Abramson
- The Journal of rheumatology. Supplement
- 1 April 2004
Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease
To characterize the diversity and taxonomic relative abundance of the gut microbiota in patients with never‐treated, recent‐onset psoriatic arthritis (PsA).
Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.
OBJECTIVE To profile the abundance and diversity of subgingival oral microbiota in patients with never-treated, new-onset rheumatoid arthritis (RA). METHODS Periodontal disease (PD) status,… Expand
The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction.
Although multiple cell types are present in the rheumatoid joint, the fibroblast-like synovial cell (FLS) is among the most prominent. It is now appreciated that the FLS is not only space-filling,… Expand
Developments in the scientific understanding of osteoarthritis
Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors – such as advancing age, obesity, and trauma – that conspire to incite a cascade… Expand
A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.
- A. Amin, M. Attur, +5 authors S. Abramson
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 26 November 1996
Tetracyclines have recently been shown to have "chondroprotective" effects in inflammatory arthritides in animal models. Since nitric oxide (NO) is spontaneously released from human cartilage… Expand