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Cyclooxygenase in biology and disease
TLDR
The current understanding of the role of cyclooxygenase‐1 and ‐2 in different physiological situations and disease processes ranging from inflammation to cancer is summarized.
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.
TLDR
In patients with persistently active rheumatoid arthritis despite methotrexate therapy, repeated doses of infliximab in combination with methotRexate provided clinical benefit and halted the progression of joint damage.
IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells1
TLDR
The data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses and was more potent than the combination of IL-2 and IL-10.
Identification and characterization of circulating human transitional B cells.
TLDR
Interestingly, circulating B cells that phenotypically and functionally resemble murine T2 B cells are found in cord blood and adult peripheral blood, suggesting that B-cell maturation may not be restricted to the spleen.
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
TLDR
TNF has a novel action in modulating autoimmunity, by inhibiting CD4+CD25+ Treg activity, through signaling through TNFRII that is constitutively expressed selectively on unstimulated Tregs and that is up-regulated by TNF.
Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus1
TLDR
There are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy, and CD27high plasma cells showed a similar degree of somatic hypermutation, but preferentially employed VH4 family members.
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
TLDR
It is found that 1,25(OH)2D3 may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B Cell-mediated autoimmune disorders.
Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.
TLDR
All dosages of celecoxib were efficacious in the treatment of rheumatoid arthritis and did not affect COX-1 activity in the GI tract mucosa as evidenced by less frequent incidence of endoscopic ulcers compared with naproxen.
Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-61
TLDR
It is demonstrated that although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells, explaining howIL-21 can be proapoptotic for B cells in vitro yet critical for Ag-specific Ig production in vivo.
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