• Publications
  • Influence
Cyclooxygenase-2--10 years later.
  • B. Hinz, K. Brune
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 February 2002
The enzyme cyclooxygenase (COX) catalyzes the first step of the synthesis of prostanoids. In the early 1990s, COX was demonstrated to exist as two distinct isoforms. COX-1 is constitutively expressedExpand
Reversal of pathological pain through specific spinal GABAA receptor subtypes
Inflammatory diseases and neuropathic insults are frequently accompanied by severe and debilitating pain, which can become chronic and often unresponsive to conventional analgesic treatment. A lossExpand
Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man
For more than three decades, acetaminophen (INN, paracetamol) has been claimed to be devoid of significant inhibition of peripheral prostanoids. Meanwhile, attempts to explain its action byExpand
Drug utilisation on a preterm and neonatal intensive care unit in Germany: a prospective, cohort-based analysis
PurposeThis study aims to describe the drug use on a Neonatal Intensive Care Unit (NICU) at a University Children’s Hospital in Germany, to investigate the licensing status of the drugs used and toExpand
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic
Dipyrone (INN, metamizol) is a common analgesic used worldwide. Its widespread prescription or over‐the‐counter use in many countries (e.g., Brazil, Israel, Mexico, Russia, Spain) requires insightExpand
New insights into the use of currently available non-steroidal anti-inflammatory drugs
Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a key component of theExpand
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
Blockade of prostaglandin (PG) production by COX inhibitors is the treatment of choice for inflammatory pain but is also prone to severe side effects. Identification of signaling elements downstreamExpand
The Impact of Unlicensed and Off-Label Drug Use on Adverse Drug Reactions in Paediatric Patients
AbstractBackground and objective: Many drugs that are used to treat children are either not licensed for use in paediatric patients (unlicensed) or prescribed outside the terms of the product licenceExpand
Suppressed Injury-Induced Rise in Spinal Prostaglandin E2 Production and Reduced Early Thermal Hyperalgesia in iNOS-Deficient Mice
It is widely accepted that peripheral injury increases spinal inducible cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) formation as key mediators of nociceptive sensitization. Here, weExpand
Comparison of rofecoxib, celecoxib, and naproxen on renal function in elderly subjects receiving a normal‐salt diet
This study compared directly the renal effects of two selective cyclooxygenase (COX)‐2 inhibitors (rofecoxib and celecoxib) with naproxen (dual COX‐1/COX‐2 inhibitor) and placebo in healthy elderlyExpand