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Isoxazoles

Known as: 1-Oxa-2-azacyclopentadiene, Isoxazoles [Chemical/Ingredient], isoxazole 
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (45)

1,2-benzisoxazole3-carbamoyl-5-methylisoxazole3-hydroxy-1,2-benzisoxazole3-isoxazolidone
In Bloodagonistsantagonists & inhibitorschemical synthesis

Broader (1)

Oxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Investigation of the Influence of CYP1A2 and CYP2C19 Genetic Polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) Pharmacokinetics in Leflunomide-Treated Patients…
Leflunomide is a disease-modifying antirheumatic drug used for the treatment of rheumatoid arthritis (RA). Cytochromes P450… 
Highly Cited
2008
Highly Cited
2008
Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
2007
2007
Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
2004
2004
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Highly Cited
2003
Highly Cited
2003
Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.
In a previous paper, we reported the N-hydroxyformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor… 
Highly Cited
2001
Highly Cited
2001
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable…
Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and… 
Highly Cited
2000
Highly Cited
2000
Synthesis of Some Fused Pyrazoles and Isoxazoles
The α-keto methylene group in 3,5-diaryl-2-cyclohexenones 2 and 3,5-diarylcyclohexanones 8 have been used to obtain fused… 
Highly Cited
1999
Highly Cited
1999
Synthesis and Absolute Stereochemical Assignment of (+)-Miyakolide
The first total synthesis of the marine macrolide miyakolide has been achieved, and its absolute stereochemistry has been… 
Highly Cited
1994
Highly Cited
1994
Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity.
A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the… 
Highly Cited
1967
Highly Cited
1967
Isoxazoles. XVIII. Synthesis and Pharmacological Properties of 5-Aminoalkyl- and 3-Aminoalkylisoxazoles and Related Derivatives.
A number of 3-substituted 5-aminoalkyland 5-substituted 3-aminoalkylisoxazoles and some related amino alcohols have been prepared… 
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