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Isoxazoles

Known as: 1-Oxa-2-azacyclopentadiene, Isoxazoles [Chemical/Ingredient], isoxazole 
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (45)

1,2-benzisoxazole3-carbamoyl-5-methylisoxazole3-hydroxy-1,2-benzisoxazole3-isoxazolidone
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In Bloodagonistsantagonists & inhibitorschemical synthesis

Broader (1)

Oxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The recent progress of isoxazole in medicinal chemistry.
Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle… Expand
Review
2018
Review
2018
Recent advance in oxazole-based medicinal chemistry.
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic ring are readily able to bind with a variety… Expand
Review
2008
Review
2008
Coinage metal-assisted synthesis of heterocycles.
2.4. Tandem sp-sp Coupling/Cyclization 3418 3. Cycloaddition Reactions 3418 3.1. [3+2] Cycloaddition 3418 3.1.1. Triazole… Expand
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Highly Cited
2008
Highly Cited
2008
Ruthenium-catalyzed cycloaddition of nitrile oxides and alkynes: practical synthesis of isoxazoles.
Isoxazoles, a major class of five-membered nitrogen heterocycles, are embedded in a number of pharmaceutically important… Expand
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Highly Cited
2005
Highly Cited
2005
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates.
Huisgen's 1,3-dipolar cycloadditions become nonconcerted when copper(I) acetylides react with azides and nitrile oxides… Expand
Highly Cited
2005
Highly Cited
2005
One-pot copper(I)-catalyzed synthesis of 3,5-disubstituted isoxazoles.
[reaction: see text] 3,5-Disubstituted isoxazoles are obtained in good yields by a convenient one-pot, three-step procedure… Expand
Highly Cited
2001
Highly Cited
2001
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
How do drugs of abuse modify neural circuitry and thereby lead to addictive behaviour? As for many forms of experience-dependent… Expand
Highly Cited
2001
Highly Cited
2001
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
A compelling model of experience-dependent plasticity is the long-lasting sensitization to the locomotor stimulatory effects of… Expand
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Highly Cited
2000
Highly Cited
2000
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Fast excitatory neurotransmission in the central nervous system occurs at specialized synaptic junctions between neurons, where a… Expand
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Highly Cited
1975
Highly Cited
1975
INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY NIPECOTIC ACID, VARIOUS ISOXAZOLES AND RELATED COMPOUNDS
—A variety of isoxazoles structurally related to muscimol (3‐hydroxy‐5‐aminomethylisoxazole) were tested as inhibitors of the… Expand
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