Isoxazoles

Known as: 1-Oxa-2-azacyclopentadiene, Isoxazoles [Chemical/Ingredient], isoxazole 
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
National Institutes of Health

Papers overview

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2013
2013
The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an… (More)
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Highly Cited
2012
Highly Cited
2012
Impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its… (More)
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2011
2011
A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (10-13) and isoxazoles (14, 15) were prepared from the synthetically… (More)
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2009
2009
A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts… (More)
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Highly Cited
2008
Highly Cited
2008
We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor… (More)
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2008
2008
Curcumin binds to the amyloid beta peptide (Abeta) and inhibits or modulates amyloid precursor protein (APP) metabolism… (More)
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2003
2003
The 3-unsubstituted isoxazole ring in the anti-inflammatory drug leflunomide undergoes a unique N-O bond cleavage to the active… (More)
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Highly Cited
2001
Highly Cited
2001
How do drugs of abuse modify neural circuitry and thereby lead to addictive behaviour? As for many forms of experience-dependent… (More)
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Highly Cited
2001
Highly Cited
2001
A compelling model of experience-dependent plasticity is the long-lasting sensitization to the locomotor stimulatory effects of… (More)
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Highly Cited
2000
Highly Cited
2000
Fast excitatory neurotransmission in the central nervous system occurs at specialized synaptic junctions between neurons, where a… (More)
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