Isoxazoles

Known as: 1-Oxa-2-azacyclopentadiene, Isoxazoles [Chemical/Ingredient], isoxazole 
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
National Institutes of Health

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Narrower (45)

1,2-benzisoxazole3-carbamoyl-5-methylisoxazole3-hydroxy-1,2-benzisoxazole3-isoxazolidone
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In Bloodagonistsantagonists & inhibitorschemical synthesis

Broader (1)

Oxazoles

Papers overview

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2013
2013
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an… (More)
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Highly Cited
2012
Highly Cited
2012
Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD
Impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its… (More)
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2011
2011
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
A new class of oxazolyl/thiazolylsulfonylmethyl pyrazoles (10-13) and isoxazoles (14, 15) were prepared from the synthetically… (More)
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2009
2009
Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.
A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts… (More)
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Highly Cited
2008
Highly Cited
2008
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor… (More)
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2008
2008
Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?
Curcumin binds to the amyloid beta peptide (Abeta) and inhibits or modulates amyloid precursor protein (APP) metabolism… (More)
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2003
2003
In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome…
The 3-unsubstituted isoxazole ring in the anti-inflammatory drug leflunomide undergoes a unique N-O bond cleavage to the active… (More)
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Highly Cited
2001
Highly Cited
2001
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
How do drugs of abuse modify neural circuitry and thereby lead to addictive behaviour? As for many forms of experience-dependent… (More)
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Highly Cited
2001
Highly Cited
2001
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
A compelling model of experience-dependent plasticity is the long-lasting sensitization to the locomotor stimulatory effects of… (More)
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Highly Cited
2000
Highly Cited
2000
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Fast excitatory neurotransmission in the central nervous system occurs at specialized synaptic junctions between neurons, where a… (More)
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